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Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/14/2021 4:56:35 PM
Research Description
Sumita Bhaduri-McIntosh is a physician-scientist whose research bridges the fields of Virology, Oncology and Immunology. Research in the Bhaduri laboratory is focused on discovering fundamental biological pathways and understanding cancer development and progression by studying the interaction between Epstein-Barr virus (EBV; a cancer-causing herpesvirus) and its host, the B cell, by investigating two main areas: 1) investigating how EBV subverts anti-pathogen and anti-cancer barriers such as immune responses and the DNA-damage response (DDR) to drive B cell proliferation and transformation, and 2) identifying host factors that determine susceptibility of EBV-infected B cells to lytic activation, a process important for herpesvirus pathology and persistence in humans, and for lymphomagenesis.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2021 12:55:54 PM
Research Description
Biochemistry of DNA replication and repair; dynamic protein DNA interactions and enzyme mechanisms required for these processes.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2021
Research Description
Characterize the immune suppressor mehanisms involved in the develeopment of HCC in the background of cirrhosis to identify novel targets that can lead to development of new immune activating strategies, predictive and prognostic biomarkers.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/10/2021 9:31:08 AM
Research Description
My laboratory is examining mechanisms for loss of human beta cells in type 1 diabetes and ways to regenerate functional beta cell mass. We are also examining the mechanisms underlying a smaller pancreas size in at risk first degree relatives and patients with type 1 diabetes. Studies are conducted using human biospecimens, isolated islets, mouse models (transgenic and AAV-injected) and beta cell lines with experiments focused on the role of neurotransmitters and neurohormones in beta cell regeneration and gene expression within endocrine and exocrine cells. Techniques include IHC, ISH, laser microdissection, optical clearing, microscopy (brightfield, fluorescence, confocal, lightsheet), in vitro cell proliferation/apoptosis, transfection, RNA and RNAseq analysis, Western blot, and other molecular biology techniques.
Department:
Oral Surgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/10/2021 1:11:49 PM
Research Description
Molecular processes that lead to the establishment of chronic pain. Development of therapeutic interventions for the treatment of trigeminal neuralgia.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/14/2021
Research Description
The current research projects are studies of microRNAs in the regulation of toll-like receptor signaling pathways in innate immune response and their relationship to periodontal disease
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/9/2021 2:35:15 PM
Research Description
mechanisms of prostate and kidney cancer growth and metastasis, vesicle trafficking.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/9/2021 1:11:37 PM
Research Description
The Davey lab is currently studying the interrelationship between surface translocation, sphingolipid synthesis, and the pathogenicity of the oral anaerobe, Porphyromonas gingivalis.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
9/26/2016
Research Description
Dr. Flores joined the University of Florida faculty to become part of the Preston A. Wells Jr. Center for Brain Tumor Therapy in order to focus on developing novel approaches to target brain tumors. She has developed a pre-clinical platform that utilizes tumor-specific autologous immune cells to efficiently target intracranial tumors. Her research interests are primarily in determining biological interactions between various cellular compartments involved in adoptive immunotherapy. Her studies also focus on leveraging systemic toxicity of frequently practiced clinical treatments in order to further enhance anti-tumor efficacy of immunotherapy.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2020
Research Description
Molecular mechanisms of periodontal diseases. Oral microbiome-host interactions Metatranscriptome of the oral microbiome in health and disease
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/10/2021 1:20:38 PM
Research Description
His main research interests are the development of novel mass spectrometry technologies for clinical research such as metabolomics, lipidomics, and imaging mass spectrometry applied to biomedical applications. His lab also works on bioinformatics methods to better understand the complexity of data generated.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Pathogenesis and treatment of Alzheimers and other Neurodegenerative disease rAAV based modeling and therapeutics Systems Biology of AD
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/10/2021 4:11:19 PM
Research Description
Our laboratory studies the interplay between epigenetics and chromatin organization in acute myeloid leukemia (AML) and in pre-leukemic conditions. We use biochemistry, cell-based assays, -omics approaches, and genetic in vivo models to understand the molecular mechanisms that drive pre-leukemic clonal evolution and lead to malignant transformation. Our goal is to find and evaluate therapies that will help cancer patients.
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2021
Research Description
Brain tumor immunotherapy. Chemokines and chemokine receptors in glioma. Focus on glioblastoma and pharmacological targeting using pre-clinical animal models
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2021 1:02:10 PM
Research Description
Dr. Heldermon's primary focus is on developing new therapeutic strategies using gene therapy and stem cell therapy for patients with lysosomal storage disorders. He also studies therapy approaches for cancer focusing on breast and sarcoma.
Department:
Physical Therapy
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/9/2021 1:00:58 PM
Research Description
Dr. Hepple leads a lab focused upon understanding the mechanisms of skeletal muscle atrophy in aging and age-related diseases, with a particular focus on the role of the mitochondrion. The lab employs a wide range of techniques, from cutting-edge mitochochondrial function assessments to genetic manipulation in rodent models.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/10/2021 2:02:45 PM
Research Description
Research in the Huang lab is concentrated on elucidating molecular mechanisms associated with breast and ovarian cancer metastasis.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2021 1:03:15 PM
Research Description
Chemoresistance in breast and prostate cancer, Nuclear Structure and Function, Epigenetic Regulation of Gene Expression. tumor Suppression
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/10/2021 11:12:03 AM
Research Description
Molecular mechanisms of host-pathogen interactions; virulence mechanism of Pseudomonas aeruginosa infection and development of antimicrobial strategies; Cellular reprogramming and genome editing
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/9/2021 5:02:23 PM
Research Description
My research interest is focused on understanding the signaling basis of cancer metabolism, particularly the function of metabolic enzymes and onco-metabolites in cancer and drug resistance. An ultimate goal is to apply the obtained insights to the development of novel therapeutics for cancer.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2021 1:03:59 PM
Research Description
Dr. Jobin works on microbiota and host response in the context of inflammation and carcinogenesis. His laboratory uses genomic, high throughput bacterial culture and gnotobiotic technology to dissect relationship between diet, inflammation and medication on bacteria-induced diseases.
Department:
Physical Therapy
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/16/2021
Research Description
The overall aim of our research lab is to elucidate the molecular mechanisms which cause skeletal muscle atrophy and associated pathologies in response to chronic diseases, such as cancer, as well as other pathophysiological conditions. In doing so, we aim to identify targets for therapeutic intervention. To address this aim we utilize a reverse translational approach which includes the study of patient tissues, rodent models, and cell-based models. This approach allows for clinically relevant observations to drive our pre-clinical mechanistic studies in which targets of interest are manipulated to implicate or eliminate their role in the pathological phenotype.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/30/2020
Research Description
Dr. Kaye has a longstanding research interest in cancer genetics and translational clinical research. His lab studies the functional properties of a cAMP/CREB/CRTC pathway that is activated in cancer by loss of LKB1/AMPK signals in lung cancer. He also studies oncolytic virotherapy for small cell lung cancer with plans for a phase 1 clinical trial.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/19/2019 9:44:16 AM
Research Description
Mammalian cell culture systems. Epigenetic regulation of transcription; chromatin structure and function; epigenetic silencing of tumor suppressor genes in cancer; single-molecule analysis of chromatin structure
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2020
Research Description
Breast cancer research, inflammation, obesity, cancer immunology
Department:
Urology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/14/2021
Research Description
Our research is focused on tumor immunology, including cancer immunotherapy, mechanisms of cancer inflammation and immune escape in both experimental and clinical settings.
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/9/2021 12:59:32 PM
Research Description
Our research focuses on the roles of the CUB Domain-Containing Protein 1 (CDCP1) protein which facilitates the invasion, survival, and metastasis of breast tumors, and the TRAIL/Death Receptor 5 (DR5) pathway that selectively kills cancer cells. We are investigating therapeutic strategies for blocking the oncogenic functions of CDCP1, and have identified a novel class of agents that activate DR5 to kill cancer cells by promoting disulfide bond-dependent DR5 clustering and downstream activation of the pro-apoptotic Caspase enzymes.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/9/2021 4:10:55 PM
Research Description
Cancer epigenetics focusing on enzymes (KATs and HDACs) that regulate protein acetylation using molecular, cellular and chemical biology approaches. We are also interested in discovering and optimizing small-molecule inhibitors of these enzymes for cancer therapy. Cancer metabolism is another area of research interest.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/16/2020
Research Description
Jonathan D. Licht, MD, is the Director of the University of Florida Health Cancer Center, Dr. Licht's laboratory studies aberrant epigenetics and gene regulation as a cause of hematological and other malignancies
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/10/2021 8:46:40 AM
Research Description
Epigenetic and metabolic regulation of tumor progression and therapeutic resistance.
Department:
Medicinal Chemistry
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/30/2020
Research Description
Dr. Luesch’s multidisciplinary research program at the interface of chemistry and biology combines classical natural products chemistry with high-throughput screening and chemical genomics. It involves most aspects of drug discovery ranging from the collection of promising marine organisms, bioassay development, NMR spectroscopic structure determination, total synthesis, mechanism-of-action studies, and pharmacology, up to the preclinical and clinical development of candidate molecules. His lab is producing a small but increasing pipeline of bioactive compounds that are at various developmental stages. He also uses functional genomics approaches to identify and characterize genes associated with disease processes, especially cancer and neurological disorders.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/9/2021 4:52:25 PM
Research Description
Approximately 15% of cancers diagnosed were attributed to carcinogenic viral infections. Upon viral infections, the host innate immune system acts as the first line of defense to prevent viral invasion or replication, while viruses also strive for survival by repressing innate immune signaling. By further understanding how innate immunity is regulated by tumor viruses, our lab aims to dissect the interactions between innate immune responses and viral tumor development. Our long-term goal is to identify potential targets and strategies for viral cancer treatment. Utilizing molecular biology as well as bioinformatics tools, our lab seeks to extend our knowledge of how viral proteins regulate the cGAS-STING pathway and how to develop potential KSHV cancer therapy by targeting these viral proteins. Specifically, we are focusing on: 1) Exploring detailed mechanisms of cGAS-STING signaling regulation by KSHV viral proteins 2) Exploring the role of KSHV viral proteins on KSHV pathogenesis in vitro and in vivo 3) Screening for novel cGAS-STING pathway agonists, and testing their efficacy using PEL based xenograft mouse model
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/18/2021 3:36:00 PM
Research Description
My research employs proteomics, RNA-seq and capture-seq to study transcriptional networks associated with gammaherpesvirus infections, and to discover new viruses in human diseases of unknown etiology or emerging epidemiology, at the human animal or vector interface, and in the context of immunocompromise or cancer. Special emphasis is on elucidating complex molecular mechanisms of Epstein-Barr virus lytic activation, immune subversion, and cellular transformation relevant to virus-induced cancer as well as exploiting EBV to immortalize human B-cells to identify and clone antiviral antibodies.
Department:
Infectious Diseases and Immunology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/30/2020
Research Description
Host and viral protein interactions relevant to therapeutic and vaccine development, Retrovirus vector for gene transfer based on foamy virus.
Department:
Vet Med- Research
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
8/25/2020
Research Description
Osteosarcoma; Melanoma vaccine; Stereotactic radiosurgery; Targeted radiotherapy; Tumor suppressor genes; single cell genomics
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/9/2019
Research Description
Immunotherapy of adult and pediatric brain tumors. Mechanisms of resistance in brain tumors to immunologic rejection. Combinatorial therapeutics involving chemotherapy, radiation, and immunotherapy
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/16/2020
Research Description
Development of novel therapy for colorectal and breast cancers.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2021 1:09:24 PM
Research Description
Cytosine methylation is a heritable epigenetic modification affecting gene transcription and the integrity of the genome. In human malignancies, aberrant DNA methylation is the most commonly observed epimutation, often manifested by promoter hypermethylation of tumor suppressor genes and hypomethylation of intergenic non-coding regions. The DNA methyltransferases (DNMTs) DNMT1, DNMT3A, and DNMT3B are the enzymes primarily responsible for methylation of CpG dinucleotides in mammalian DNA. Mutations in the coding sequence of DNMT3A are frequently found in human hematologic malignancies indicating that decreased DNMT3A activity may promote tumorigenesis in multiple hematopoietic lineages. Using targeted inactivation of Dnmt3a in mice Opavsky lab showed that Dnmt3a plays a tumor suppressor role in prevention of chronic B-cell lymphocytic leukemia, peripheral T cell lymphoma and myeloproliferative disease. Furthermore, Dnmt3b is a tumor suppressor gene in prevention of MYC-induced T cell lymphomas. Promoter hypomethylation accompanied by increased gene expression was found to be a frequent event in both mouse and human hematologic malignancies.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2020
Research Description
Immune recognition, structural biology and drug discovery; cancer research; immunological regulation by T cells; structural interactions defined by X-ray crystallography and functional studies; drugs to prevent and treat COVID-19 .
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/9/2021 3:17:54 PM
Research Description
Interdisciplinary biomedical research; revealing genome-wide switch mechanisms of health vs. disease; epigenetic and signaling regulation of cell identity; mechanisms of tumorigenesis; oncogenic viral infections.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/9/2021 3:11:41 PM
Research Description
The long-term goal of my research is to understand the mechanisms that underlie the development of blood cancers with a focus on studying the genetic pathways that control the proliferation, survival and self-renewal of normal or leukemic hematopoietic stem cells. The current main research focuses: 1. Molecular regulation of normal hematopoietic stem cell (HSC) and its leukemic transformation 2. The role of the Wnt/beta-catenin signaling in the development and maintenance of myeloid neoplasms 3. Transcriptional, epigenetic and epitranscriptomic regulation of normal hematopoiesis and leukemogenesis 4. Development of targeted therapies for myeloid malignant diseases
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/9/2021
Research Description
Biology of Kaposi's sarcoma-associated herpesvirus (KSHV); role of latency-associated nuclear antigen (LANA) in transcriptional regulation, viral DNA replication, and episomal segregation in latently-infected cells; role of virus-encoded micro RNAs.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2021 9:11:20 AM
Research Description
Characterization and manipulation of adult neural stem cells. Cancer stem cells Brain cancer The application and impact of natural products, cannabinoids and psychedelics in augmenting CNS function
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2021 1:59:49 PM
Research Description
Topoisomerases; cancer and microbial chemotherapy; mitochondrial DNA; chromatin structure. Malaria, plastid/organellar DNA and anti-malarial drugs.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/10/2021 10:18:56 AM
Research Description
Cellular and biochemical mechanisms by which G protein-coupled receptors activate physiologically important tyrosine kinase signaling pathways.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/30/2020
Research Description
Current interests include developing innovative immunotherapeutics for pediatric tumors and invasive central nervous system malignancies. Dr. Sayour’s main focus is deeply rooted in harnessing the immune system to eradicate pediatric cancers. Dr. Sayour has extensive translational experience as PI/Co-I on several human trials (i.e. lead-PI on the first-in-human ACTION Trial- Adoptive Cellular Therapy following Dose-Intensified Temozolomide in Newly-diagnosed Pediatric High-grade Gliomas, NCT03334305). His translational efforts are also focused on new pipeline technologies including a novel lipid-nanoparticle (NP) formulation that he pioneered for the immunologic treatment of cancer. Dr. Sayour has spearheaded new paradigm treatments currently being tested in canine (pet dog) patients with terminal brain cancer (UFIACUC#201609430) before translation into dedicated human studies.
Department:
Pharmaceutics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/28/2018
Research Description
Dr. Schmittgen's research focuses on noncoding RNAs and cancer, with emphasis on the use of microRNAs as therapeutic or diagnostic agents. A paper he co-authored in 2001 describing the relative method of gene quantification has been cited over 36,000 times and was recently ranked by the international journal Nature as the 21st most-cited scientific article of all time. His lab was the first to establish a link between altered microRNA expression in pancreatic cancer and the intellectual property resulting from this work is the basis of the product miRInform Pancreas™, a biomarker of early pancreatic cancer development. Recently, he has focused his attention on the development of microvesicles as targeted drug delivery systems for the treatment of cancer.
Department:
Radiation Oncology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2020
Research Description
Our research laboratory seeks to improve cancer therapies through molecular targeting strategies and physiologic interventions such as exercise. A primary focus is the tumor microenvironment which not only influences treatment resistance of cancer to conventional anticancer therapies but also plays a critical role in neoplastic cell initiation, malignant progression, and metastatic spread to secondary sites.
Department:
Mechanical & Aerospace Engineering
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/10/2021 10:40:53 AM
Research Description
Dr. Tang's research interests include cell and molecular mechanics in cancer development and metastasis, cardiovascular systems, and brain; biophysics; unconventional mechano-electrophysiology; quantitative in vivo/vitro functional bio-imaging; nanotechnology; and genome engineering
Department:
Surgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/10/2021 9:40:09 AM
Research Description
The lab of Dr. Thomas investigates the role of the microbiome in pancreatic carcinogenesis. They were one of the first labs to identify that the intestinal microbiota can accelerate pancreatic cancer progression and currently is focused on how bacterial metabolites regulate the immune system to modulate pancreatic cancer development.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/26/2021
Research Description
Oncogenic virus pathogenesis, noncoding RNAs, virus-host interactions, host immunity to viruses, viral latency.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/10/2021 9:54:43 AM
Research Description
Pathogenesis of oncogenic herpesviruses, epigenetic regulation of gammaherpesvirus infection, regulation of viral latency and lytic activation, coronavirus infection
Department:
Neurosurgery
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/16/2020
Research Description
Research in the Tran lab focuses on understanding the molecular mechanism of how cancer develops, progresses, and resists treatments through an integrated approach from clinical observations to systems and computational biology, and to animal models and quantitative molecular validation, with the ultimate goal of returning to human patients to develop novel, safe and effective anti-cancer therapeutics.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/10/2021 8:02:36 AM
Research Description
Mutation and analysis of human disease and susceptibility genes.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/16/2021
Research Description
We are studying cancer cell signaling with expertise in signal transduction, genetic and epigenetic regulation, and animal models. Our current laboratory research is centered on two families of transcriptional co-activators, MAML and CRTC, which are essential components of Notch receptor signaling and LKB1-CRTC/CREB signaling pathways, respectively. We are investigating the molecular regulation and the roles of deregulated cell signaling in cancer generation and progression, with the goal of gaining molecular insights into cancer pathogenesis and identifying novel cancer diagnostic and therapeutic targets.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2021 2:02:12 PM
Research Description
The Xie Lab’s research interest is to decipher biogenesis pathways that generate RNAs essential for gene expression in metazoans and associated Herpesviruses. Our current focus is on microRNAs, small non-coding RNA molecules that control the function of other genes. In the near future, we will integrate approaches from biochemistry, cell biology, virology and bioinformatics to study viral and cellular non-canonical microRNA biogenesis pathways, which surprisingly incorporate several fundamental cellular machineries involved in processing other classes of RNAs. Our efforts will provide a better basis for developing novel therapeutics that alter microRNA levels to combat a variety of diseases, including Herpesvirus-induced malignancies and other cancers.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/14/2021 4:53:28 PM
Research Description
Mechanism of oncogenic transformation. Cooperation of oncogenes and suppressor genes in cancer development. Genetically engineered mice models for cancer. Targeted therapeutics in pancreatic and lung cancer models.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/9/2021 3:08:38 PM
Research Description
Primary research interest focuses on the pathogenesis and therapy of breast cancer. The Zhang Lab studies the dynamic interactions between cancer cells and various tumor microenvironment components especially immune cells during the pathogenesis of breast cancer. The goals are to provide strong rationale for novel target identification, novel drug development, and/or formulation of novel treatment regimens for breast cancer patients. In addition, the Lab has broader interest in other cancer types including renal cancer. The lab has been establishing the immune landscaping of renal clear cell carcinomas (RCC) using single cell RNA sequencing/bioinformatics. This leads to several novel discoveries that may explain the sensitivity of RCC to immunotherapy.
Department:
Pharmacodynamics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/9/2021 4:12:42 PM
Research Description
Dr. Zhou’s research has been focused on development of novel targeted therapeutics for cancer and various age-related diseases investigation. His studies has led to a better understanding of the role of senescent cells in IR and chemotherapy caused normal tissue damage and the discovery of the first potent and broad-spectrum senolytic drug, ABT263-a specific Bcl-2/xl inhibitor, that can selectively kill senescent cells to rejuvenate both prematurely senescent tissue stem cells induced by IR and tissue stem cells in normally aged mice. This discovery may lead to new therapeutics for various age-related diseases and the side effects induced by chemotherapy and IR. More recently, he developed several proteolysis targeting chimeras (PROTACs) that can target Bcl-xl and other proteins of interest for degradation via the ubiquitination and proteasome system. He found that Bcl-xl PROTACs can selectively induce Bcl-xl degradation in senescent cells and various cancer cells but not in platelets, suggesting that Bcl-xl PROTACs have the potential to be developed as a better senolytic and anticancer agent than ABT263 by not causing thrombocytopenia. Using the PROTAC drug development platform, he is developing additional specific antitumor agents.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2021
Research Description
Apoptosis, regulation of innate immunity, innate immunity against tumor cells.

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