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Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/25/2019
Research Description
Structure to function correlations for ssDNA viruses; vaccine development, antigens delivery systems, gene therapy immunology of gene therapy; X-ray crystallography, cryo-electron microscopy.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/5/2019
Research Description
My research area is to elucidate the regulatory pathways of oral bacteria, with particular focus on biofilm formation and stress tolerance that can modulate the virulence of oral bacteria and enhance the pathogenic potential of oral biofilms. Stemming from the original AtlA work, another major research area is to investigate the molecular basis for regulation of autolysis of S. mutans by gene products that have major effects on traits related to virulence. This research focuses on the characterization of a pair of dicistronic operons, lrg and cid-like, that significantly affected autolysis and biofilm formation by S. mutans.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/15/2019 2:02:48 PM
Research Description
Biochemistry of DNA replication and repair; dynamic protein DNA interactions and enzyme mechanisms required for these processes.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2015 4:52:32 PM
Research Description
Streptococcal protein translocation; stress responses; membrane biogenesis; biofilm formation; bacterial adhesion; functional amyloid formation; host/pathogen interactions; immunomodulation by monoclonal antibodies; structure/function of streptococcal sur
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/8/2019
Research Description
The goal of our work is to understand how misfolded alpha-1-antitrypsin causes cellular injury in liver and innate immune cells and to develop rational therapies to modulate this injury. To accomplish this goal we use cellular and animal models and transl
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/20/2019
Research Description
The overarching focus of our work is the study of how cells maintain genomic homeostasis and how alterations in the genome and epigenome impact the process of tumorigenesis.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/12/2017 9:11:54 AM
Research Description
Cell biology and biochemistry of actin-binding proteins involved in apoptosis, angiogenesis, neural plasticity and cancer biology.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/5/2019 9:21:19 AM
Research Description
Analysis of long distance gene regulation by enhancers and locus control region. Genomic and proteomic analysis of erythroid transcription factors. Modulation of gene expression using synthetic zinc finger proteins.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/1/2019 11:50:09 AM
Research Description
Environmental regulation of bacterial gene expression and virulence.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/7/2017
Research Description
Regulation of Edn1 gene expression in the kidney.

William L. Clapp, M.D.

Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/19/2019 1:05:16 PM
Research Description
kidney development, regenerative biology and disease
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/17/2019
Research Description
Mycobacterium tuberculosis, the causative agent of tuberculosis. Investigate how these bacteria survive and grow within human cells to cause TB. We are using this knowledge to develop a safe, effective vaccine to protect people against infection. We are expanding our research focus to include development of a vaccine to protect against infection by non-tuberculous mycobacteria (NTMs), especially M. abscessus and M. avium.

Patrick J. Concannon, Ph.D.

Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/25/2019 3:49:35 PM
Research Description
Research focuses on complex genetic disorders and gene-environment interactions, and includes studies of radiation sensitivity, breast cancer, and type 1 diabetes
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/5/2019
Research Description
Investigation of renal, cardiovascular, placental and endometrial function in normal and pathological pregnancies
Department:
Food Science & Human Nutrition
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/19/2019 12:32:30 PM
Research Description
Molecular and cell biology of zinc metabolism and function.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/5/2019 11:20:38 AM
Research Description
Metabolism-Diabetes (T2DM); Obesity; Fatty Liver Disease (NAFDL). The main goals of our lab are to understand the metabolic and molecular pathways of T2DM, obesity and NAFLD.
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2018 11:44:55 AM
Research Description
Interests of the Dame lab include emerging and re-emerging pathogens of animals and man; molecular biology of the malaria parasite; drug and vaccine target identification in Plasmodium falciparum. Current projects include: Refinement of ultrasensitive test for malaria infection Selective pressures exerted on the malaria parasite by novel mosquito vectors
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/19/2019 9:07:16 AM
Research Description
Environmental reproductive toxicology in wildlife.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/5/2019
Research Description
Molecular biology and genetics of RNA virus replication. Development of noninfectious VLP vaccines for poliovirus and other picornaviruses.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/25/2019 9:03:36 AM
Research Description
Over the last five years, my lab has explored the function of carbonic anhydrase IX (CAIX) expression and activity in breast cancer. We hypothesize that CAIX is involved in regulating extracellular pH to the advantage of tumor cells.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/19/2019 12:37:53 PM
Research Description
His main research interests are the development of new mass spectrometry technologies for clinical applications such as metabolomics and imaging mass spectrometry applied to biomedical applications. A major goal is to train the next generation of bioanalytical scientists in translational research.
Department:
Orthopaedics & Rehabilitation
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/19/2019
Research Description
Vector development and gene delivery approaches for the treatment and repair of musculoskeletal disorders, including osteoarthritis and cancer. Mechanisms driving intra-tumoral heterogeneity, immune evasion, metastasis and chemotherapy resistance in sarcoma.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/25/2019 9:42:39 AM
Research Description
The Gumz laboratory is investigating the role of the circadian clock in the kidney. The focus is on the regulation of renal sodium and potassium handling, which is critical to the control of blood pressure as well as to overall cardiovascular health.
Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/7/2017
Research Description
Loss of arable lands
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/21/2019
Research Description
Development of anti-infective countermeasures for bacterial infections of bio-warfare or bio-terrorism potential. Development of aerosol infection models.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/8/2019 1:44:54 PM
Research Description
Dr. Heldermon's primary focus is on developing new therapeutic strategies using gene therapy and stem cell therapy for patients with inherited diseases such as lysosomal storage disorders and hemophilias. He is focused on studying the frequent cell transfer between mother and fetus during gestation that establish microchimerism and is determining ways to modulate the level of this chimerism to enable therapy of disease. Through the use of gene replacement, he hopes to correct the underlying deficiencies underpinning the disease manifestations. • Additionally he is studying the spread of breast malignancies through the use of xenografting. By studying the spread of tumors from breast cancer patients in mice, he hopes to determine if metastases is determined by tumor specific or host factors. This model will allow identification of what factors are important in tumor spread and localization. Additionally, the model will allow testing of therapeutic agents. The goal is to identify new targets for therapy to personalize oncologic therapeutics.
Department:
Orthodontics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/9/2019 12:21:23 PM
Research Description
Regulation of bone remodeling and the generation of new tools for the treatment of bone disease. Recent studies are focused on extracellular vesicles (exosomesinvolved in regulating bone remodeling and on the generation of bone biomimetics.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/24/2019 9:52:19 AM
Research Description
Chemoresistance in breast and prostate cancer, Nuclear Structure and Function, Epigenetic Regulation of Gene Expression. tumor Suppression
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/24/2017
Research Description
Microbial pathogenesis, antibiotic resistance, microbial genetics, molecular epidemiology, microbial ecology.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/5/2019 10:13:40 AM
Research Description
Our current research interest is to understand the function of Nkx2.5, an evolutionarily conserved NK2 class of homeobox transcription factor in mature cardiomyocytes. Within the genomic analysis of cardiovascular diseases, mutations of NKX2.5 (capitals
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/1/2016
Research Description
Molecular basis for human cancer and the clinical management of patients with thoracic malignancies.
Department:
Pharmacodynamics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/5/2019 8:49:20 AM
Research Description
My research interests are the adaptations in endocrine and cardiovascular systems in pregnancy and at birth. The current focus of my research is fetal and neonatal metabolism, including 1)the effect of glucocorticoids on fetal cardiac metabolism and function, and the transition at birth, 2) effects of exposure to Triclosan (an antibacterial in many soaps), and 3) alterations in the maternal microbiome. The laboratory uses a combination of in vivo techniques, including use of telemetry to measure fetal cardiovascular function in utero, biochemical techniques, and systems biology methods- both transcriptomics and metabolomics.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/19/2019 1:12:45 PM
Research Description
My laboratory’s focus is to characterize the amino acid-responsive signaling pathways in mammalian cells, known as the amino acid response (AAR). The AAR is activated when there is a limitation of dietary protein, a dietary amino acid imbalance, or a pathological state that limits amino acids to a cell or tissue. Amino acid limitation triggers the AAR pathways that regulate a wide spectrum of cellular functions through gene transcription, mRNA stabilization, translational control, and protein turnover. The principal pathway of GCN2-eIF2-ATF4 of the AAR is conserved from yeast to humans. Our laboratory has been instrumental in identifying and characterizing the ATF4 responsive genomic elements in a spectrum of genes. We have also discovered that amino acid limitation activates MAPK cascades via a GCN2-independent mechanism and we are striving to identify the amino acid sensor that triggers MAPK signaling.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/19/2019 9:44:16 AM
Research Description
Mammalian cell culture systems. Epigenetic regulation of transcription; chromatin structure and function; epigenetic silencing of tumor suppressor genes in cancer; single-molecule analysis of chromatin structure
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Development, Implementation and Evaluation of a variety of research-aligned programs linking UF research faculty and graduate students with precollege science teachers, talented high school students, and underserved schools and communities across Florida
Department:
Periodontology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/19/2019 9:47:01 AM
Research Description
Major interests are to examine the role of major periodontal pathogens causal association with systemic diseases including atherosclerosis, rheumatoid arthritis and Alzheimer’s disease. Role of dominant microRNAs in periodontal disease.
Department:
Aging & Geriatrics Research
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/21/2019 2:26:46 PM
Research Description
Physiology, biology & biochemistry of aging, with focus on mitochondrial biology, autophagy, apoptosis and oxidative stress, aging, anti-aging interventions.
Department:
Medicinal Chemistry
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/8/2019
Research Description
Li’s scholarly interests range from organic chemistry, biochemistry, medicinal chemistry to physical chemistry, computational chemistry, molecular biophysics and pharmacology. His research focuses on molecular recognition, with a strong application to structure-based drug dresign, especially for anti-cancer and neurodegenerative diseases.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017
Research Description
Jonathan D. Licht, MD, is the Director of the University of Florida Health Cancer Center, Dr. Licht's laboratory studies aberrant epigenetics and gene regulation as a cause of hematological and other malignancies
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/5/2019
Research Description
Cerebral metabolism; development of methods to measure metabolism in vivo; protein regulation of biofilm formation; Interaction of proteins and membanes in regulating cell membrane biophysics; nuclear magnetic resonance (NMR)
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/21/2019 1:10:27 PM
Research Description
Epigenetic and metabolic regulation of tumor progression.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/9/2019 12:05:39 PM
Research Description
Application of gene transfer to study animal models of neurodegenerative disorders including Parkinson's disease, Huntington's disease, brain tumors, and ischemia.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/25/2019 11:19:51 AM
Research Description
The study of central nervous system structure and function with magnetic resonance. In particular, mapping of brain structural connectivity using diffusion-weighted magnetic resonance imaging methods and investigating the mechanism of memory modulation with transcranial electric current stimulation.
Department:
Environmental Health
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/19/2019 12:22:13 PM
Research Description
Pathogenic mechanisms of Shigella and Chlamydia Evolution and emergence of Shiga toxin-producing Shigella flexneri Cell wall metabolism and cell division processes of Chlamydia spp. Surveillance of non-HIV sexually transmitted infections in Haiti Laboratory capacity building
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2018 10:53:49 AM
Research Description
Molecular mechanisms of hematopoietic growth factor-induced cell signaling events regulating cell growth & apoptosis of normal and malignant hematopoietic cells; interleukin-3 regulation of tyrosine and serine/threonine protein kinases;
Department:
Periodontology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/19/2019
Research Description
We focus primarily on osteoimmunology, which is the study of interactions between immune cells, immune mediators, and immune signaling in skeletal biology. In particular, we study the differentiation of bone-resorbing osteoclast cells in response to bone
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/5/2019 9:35:24 AM
Research Description
Focused on the use of statistical theory to elucidate the relationship between genotype and phenotype. Currently interested in integration of omic data.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/19/2019
Research Description
Multidisciplinary approaches: including molecular biology, biophysical techniques, structural biology (cryo-EM and crystallography), and kinetics are used to study biological molecules (viruses and proteins)
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/8/2019 11:07:30 AM
Research Description
Host and viral protein interactions relevant to therapeutic and vaccine development, Retrovirus vector for gene transfer based on foamy virus.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/8/2019
Research Description
The Merritt lab is dedicated to understanding intermediary metabolism through the process of measuring metabolic flux quantitatively in living systems, including cell culture, perfused organs, and in whole animal models. Our preferred method of measuring flux is with nuclear magnetic resonance (NMR), which provides unique insights into biochemistry due to its extreme sensitivity to changes in chemical bonding. Our primary target of study is the citric acid cycle (CAC), which is the first stage of ATP production from nutrients. Flux through the CAC has been shown to be up- or downregulated in a variety of pathophysiological states. In addition, the CAC generates a variety of intermediates that are used in biosynthesis and can also serve as a “recycler” of carbon skeletons generated by processes like autophagy. While NMR is information rich, it is also characterized by poor absolute sensitivity. The other arm of my research group includes developing hardware that amplifies magnetic resonance signals, improving sensitivity and enabling a variety a new flux measurements in vivo. These methods are known collectively as “hyperpolarization”.
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/25/2019 2:14:05 PM
Research Description
Intestinal disorders (IBD, colon cancer) and oral vaccine delivery
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/24/2019 12:49:46 PM
Research Description
Development of novel therapy for colorectal and breast cancers.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/28/2018
Research Description
My main research projects focus on investigating the relationship between oral alkali production from arginine and dental caries experience in children and adults.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/24/2019
Research Description
Our research focuses on understanding the underlying molecular mechanisms controlling gene expression in the inflammatory response and in the etiology of Type 1 Diabetes.
Department:
Biomedical Engineering
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017 12:45:56 PM
Research Description
Studies how stem cell strategies could be used to repair the brain. We use the hippocampus as a model to understand how make the brain receptive to neuron addition because the hippocampus adds new neurons throughout life in all mammals, including humans
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/8/2019 2:17:26 PM
Research Description
Immunological regulation by T cells; structural interactions between ligand pairs linked to T cell interaction as defined by X-ray crystallography and functional studies.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
3/20/2018 11:18:50 AM
Research Description
Treatments for disorders that affect mitochondrial function.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/25/2019 1:47:12 PM
Research Description
Various stem cell (i.e. bone marrow, fetal, iPSCsand hepatic) biology and how they can be used as a tool in gene therapy or in their participation in liver regeneration. Also looking into how hepatic cells (hepatocytes, ductular cells, stellate cells) can be used in developing a bio-artificial liver device (BAL), bioengineering
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Neuronal cytoskeletal proteins especially microtubules, microfilaments and their associated proteins. Enzyme catalysis and regulation.

Zhijian Qian, Ph.D.

Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/21/2019
Research Description
The long-term goal of my research is to understand the mechanisms that underlie the development of blood cancer with a focus on studying the genetic pathways that control the proliferation, survival and self-renewal of normal or leukemic hematopoietic stem cells. The current main research focuses: 1. Molecular regulation of normal hematopoietic stem cell (HSC) and its leukemic transformation 2. The role of the Wnt/ß-catenin signaling in the development and maintenance of myeloid neoplasms 3. Transcriptional, epigenetic and epitranscriptome regulation of normal hematopoiesis and leukemogenesis 4. Development of targeted therapies for myeloid malignant diseases
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 1:46:35 PM
Research Description
Structure and function of Histone deacetylases, and their roles in gene regulation and cancer.
Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/28/2018
Research Description
Dr. Rivkees’ laboratory is currently focusing on the role of adenosine on cardiac development and the fetal programming of adult cardiac disease via epigenetic mechanisms. In addition, we are studying developmental brain injury, focusing on white matter injury and oligodendrocyte biology.
Department:
Anesthesiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Understanding the mechanisms behind nicotine toxicity at cellular level as it relates to alterations in gene expression.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/5/2019 3:28:47 PM
Research Description
Molecular evolution of viruses, with special emphasis on HIV and SIV. Development and application of new bioinformatics and phylogenetic analysis tools to investigate the Molecular epidemiology of viral and bacterial pathogens, with emphasis on Vibrio cholerae, MRSA and Neisseria meningiditis
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2019 2:06:21 PM
Research Description
Cellular and biochemical mechanisms by which G protein-coupled receptors activate physiologically important tyrosine kinase signaling pathways.
Department:
Obstetrics & Gynecology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/19/2019 1:24:23 PM
Research Description
Role of growth factors and proteases in ocular and skin wound healing; gene therapy using ribozymes to receptors; bacterial biofilms in chronic wounds
Department:
Whitney Laboratories
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/9/2018 12:57:21 PM
Research Description
Research focus:the cellular and molecular mechanisms of development and regeneration in annelids and other closely related marine animals. Interests: patterning of embryonic stem cells, neurogenesis, regenerative biology and patterning of the germline.
Department:
Aging & Geriatrics Research
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/24/2019 1:08:06 PM
Research Description
Molecular mechanisms underlying inner ear aging, detoxification, sex difference in aging and hearing
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/19/2019 10:07:38 AM
Research Description
For nearly four decades, Dr. Srivastava’s research has been focused on the following two parvoviruses, the non-pathogenic adeno-associated virus (AAV), and a common human pathogen, the parvovirus B19, and the development of recombinant parvovirus vectors for human gene therapy. His laboratory has made seminal contributions to the field of parvoviruses, which include: identification of cellular co-receptors for AAV as well as parvovirus B19; elucidation of various steps involved in parvovirus trafficking in the cell and nuclear transport; identification of cellular proteins involved in the regulation of AAV DNA replication and encapsidation; development of recombinant AAV and parvovirus B19 vectors; transgenic and knockout mouse models to study parvovirus-induced pathogenicity, and the use of parvovirus vectors for gene transfer and gene therapy. Parvovirus-based vectors have gained attention as a useful alternative for human gene therapy. The stable integration of the AAV genome, and the erythroid cell tropism of B19 have been exploited to construct the following two types of AAV-B19 hybrid vectors. Type I vectors allow stable integration of the viral DNA in infected cells but the viral gene expression occurs predominantly in the erythroid progenitor cells. Type II vectors allow efficient erythroid progenitor cell-specific gene delivery as well as expression of transduced genes. However, it has become increasingly clear that the full potential of the first generation of AAV vectors is unlikely to be realized. For example, AAV vectors composed of the naturally occurring capsids trigger a host immune response, especially at high doses, since specific surface-exposed amino acid residues on the naked icosahedral capsids are readily targeted by the host cell machinery. Furthermore, the AAV genome is a single-stranded DNA, which is transcriptionally-inactive, and thus negatively impacts the transduction efficiency of the first generation of AAV vectors. During the past decade, strategies have been developed in Dr. Srivastava’s laboratory that circumvent both of these problems associated with the first generation of AAV vectors. For example, specific surface-exposed amino acid residues on the AAV capsids have been modified to develop the next generation (‘NextGen’) AAV vectors that are significantly more efficient, and are less immunogenic. One of the NextGen AAV vectors has been used by other investigators in a Phase I Clinical Trial for Leber's Hereditary Optic Neuropathy (LHON), and has shown clinical efficacy. The single-stranded AAV genome has also been modified to develop generation X (‘GenX’) AAV vectors with which enhanced transgene expression can be achieved. The combination of the NextGen and the GenX vectors has resulted in the development of optimized (‘Opt’) AAV vectors that are more efficient at further reduced doses. The current emphasis is on developing recombinant parvovirus vectors for gene therapy/genome editing of genetic diseases such as beta-thalassemia and sickle cell disease, and gene therapy of malignant disorders such as hepatoblastoma and hepatocellular carcinoma.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/25/2019 12:49:45 PM
Research Description
Application of patient induced pluripotent stem (iPS) cells to clinical translational research;The role of mitochondrial ATP transporters in embryonic development, organ homeostasis and reproduction
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/24/2019
Research Description
Pathogenesis of oncogenic herpesviruses, mechanisms of viral immune evasion, epigenetic regulation of gammaherpesvirus infection, viral genetics
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/20/2019
Research Description
Mutation and analysis of human disease and susceptibility genes.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018
Research Description
Measurement of skeletal and cardiac muscle physiology, function, and metabolism using innovative NMR and MRI based techniques. Studies the effect of gene transfer/pharmacological correction from the basic cell level to humans with muscular dystrophies.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/1/2016
Research Description
We study microsatellite repeat expansion diseases, including myotonic dystrophy. We use molecular, cellular, computational, and animal-based approaches to understand basic mechanisms that cause symptoms in this and related multi-systemic diseases, as well as identify treatments that will help patients. We also study RNA localization at a basic level, to understand why and how RNA molecules move to different places in the cell. We seek to combine high-throughput genomics approaches with single molecule imaging approaches to characterize and understand this new frontier in biology.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/19/2019 8:06:41 AM
Research Description
Aldosterone action & hyperaldosteronism, renal endothelin action, hypertension, ion transporting ATPases; K+ channels; signal transduction.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/19/2019
Research Description
The Xie Lab’s research interest is to decipher biogenesis pathways that generate RNAs essential for gene expression in metazoans and associated Herpesviruses. Our current focus is on microRNAs, small non-coding RNA molecules that control the function of other genes. In the near future, we will integrate approaches from biochemistry, cell biology, virology and bioinformatics to study viral and cellular non-canonical microRNA biogenesis pathways, which surprisingly incorporate several fundamental cellular machineries involved in processing other classes of RNAs. Our efforts will provide a better basis for developing novel therapeutics that alter microRNA levels to combat a variety of diseases, including Herpesvirus-induced malignancies and other cancers.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2017
Research Description
Our lab studies the epigenetic regulation of transcription in mammals. We are interested specfically in mechanisms of epigenetic regulation by genomic imprinting in the Angelman/Prader-Willi syndrome region of human chromosome 15 (and mouse chromosome 7). We are also interested in the epigenetic effects of the prenatal environment on long-term health, particularly in fetal alcohol syndrome.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017
Research Description
AAV vector design. AAV vector production.

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