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Department:
Infectious Diseases and Immunology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 11:53:25 AM
Research Description
Cellular and molecular bases of host-parasite interactions; immunology of hemoparasitic diseases.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 12:12:08 PM
Research Description
Sumita Bhaduri-McIntosh is a physician-scientist whose research bridges the fields of Virology, Oncology and Immunology. Research in the Bhaduri laboratory is focused on discovering fundamental biological pathways and understanding cancer development and progression by studying the interaction between Epstein-Barr virus (EBV; a cancer-causing herpesvirus) and its host, the B cell, by investigating two main areas: 1) investigating how EBV subverts anti-pathogen and anti-cancer barriers such as immune responses and the DNA-damage response (DDR) to drive B cell proliferation and transformation, and 2) identifying host factors that determine susceptibility of EBV-infected B cells to lytic activation, a process important for herpesvirus pathology and persistence in humans, and for lymphomagenesis.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
7/11/2023 3:50:01 PM
Research Description
Molecular pathogenesis of the herpesviruses; role of long non-coding RNAs and miRNAs on latency and reactivation; development of novel therapeutics to disrupt HSV latency and block recurrent disease.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2023 1:22:01 PM
Research Description
Biochemistry of DNA replication and repair; dynamic protein DNA interactions and enzyme mechanisms required for these processes.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/6/2022 2:11:43 PM
Research Description
My lab uses transgenic & knockout mouse models, and cell models, to determine molecular mechanisms by which mutations in specific genes cause familial neurodegenerative diseases - primarily Alzheimer's disease and amyotrophic lateral sclerosis.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2023 1:22:24 PM
Research Description
We study how enteric viral pathogens (rotavirus, norovirus, astrovirus…) infect and replicate in the human gastro-intestinal tract. We aim at defining how host/enteric pathogen interactions is coordinated at the molecular level in space and time and how these complex interactions can either lead to pathology development or resolution of viral infection. Our goal is to exploit these mechanisms to develop novel antiviral therapeutic approaches and pharmacological interventions to treat inflammatory bowel diseases. We use a multidisciplinary approach combining molecular and cellular biology, state-of-the-art live single molecule imaging, bio-engineering (to simulate the physiological microenvironment) and single cell transcriptomic approaches. Our integrative research approach allows us to address within a tissue how individual cell types communicate together to coordinate different antiviral strategies to ultimately lead to viral clearance while maintaining tissue homeostasis.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2023 12:01:21 PM
Research Description
Optimizing gene therapy vectors (AAV) for the treatment of inherited retinal disease.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/14/2023 2:14:46 PM
Research Description
My lab studies the response of blood vessels within the lung to immunoregulatory cell recruitment, and how this may contribute to the development of high blood pressure in the lungs (pulmonary hypertension; PH), and heart failure, in patients with chronic lung diseases. Specific pathways of interest include: circadian biology influence on PH (models and patients with disease), free DNA sensing pathway, and exploring the contribution of dysautonomia to PH.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2023 1:22:29 PM
Research Description
Analysis of long distance gene regulation by enhancers and locus control region. Genomic and proteomic analysis of erythroid transcription factors. Modulation of gene expression using synthetic zinc finger proteins.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
7/20/2023 1:39:28 PM
Research Description
Jason Butler is currently a Professor and Vice Chief of Research for the Division of Hematology/Oncology at the University of Florida’s College of Medicine. His laboratory is focused on understanding the role of bone marrow endothelial cells within the instructive vascular niche in providing the correct milieu and stoichiometry of angiocrine factors to support hematopoietic stem cell (HSC) function. His research program aims to understand the mechanisms by which endothelial cells promote hematopoietic regeneration following myelosuppression in the hope of translating these findings towards therapeutic modalities to rejuvenate aged hematopoietic and vascular systems.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2021 12:57:02 PM
Research Description
Cardiovascular gene therapy; adeno-associated viral vectors.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 11:54:46 AM
Research Description
Developmental Biology & Evolution: Embryonic development; Organ formation; Evo-Devo; Molecular basis of sex differences; Genetic and environmental causes of birth defects.
Department:
Ophthalmology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 12:24:01 PM
Research Description
Dr. Dinculescu received her Ph.D. in Biochemistry from University of Florida in 2002. Her research is focused on understanding the molecular mechanisms in several retinal degeneration disorders, including Usher syndrome. The ultimate goal is to develop therapeutic strategies to prevent the loss of sight caused by these disorders. Usher syndrome type III (USH3A), an autosomal recessive disorder, is caused by mutations in Clarin-1 (CLRN1) protein, leading to combined vision and hearing loss. The main goal of this project is to understand the function of CLRN1 in the retina, identify its binding partners, and its cellular localization pattern. This information will be used to develop a rational treatment for the USH3A disorder. She is also interested in protein aggregation mechanisms leading to the formation of extracellular deposits associated with vision loss in age-related macular degeneration, a major cause of blindness in the elderly population.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/14/2023 2:56:53 PM
Research Description
The phenomenon of genomic imprinting is the differential modification of the maternal and paternal genetic contributions to the zygote, resulting in the differential expression of parental alleles during development and in the adult. A disturbance in genomic imprinting results in a number of human genetic diseases including the Prader-Willi and Angelman syndromes.
Department:
Surgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2022
Research Description
Dr. Efron has a professional interest in surgical critical care and trauma, both clinically as well as in the laboratory. He conducts basic science and translational research in sepsis and inflammation.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/12/2023 12:51:50 PM
Research Description
Effect of immunosuppression on anti-GAA antibody development in patients with Pompe disease, clinical trial studies as part of CARRA (Childhood Arthritis and Rheumatology Research Alliance)
Department:
Neurology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2023 12:53:58 PM
Research Description
Dr. Farrer's research aims to predict and prevent Parkinson’s disease through a combination of human genetic analyses, molecular genetic engineering and neuronal biology, mouse modeling, behavior, brain slice biochemistry and immunohistochemistry, electrophysiology and pharmacology. He directs the Parkinson’s Research Laboratory. Dr. Farrer also directs the Clinical Genomics Program for UF Health that seeks to improve health outcomes for patients by generating and interrogating genomic data, to accelerate diagnosis and target treatments more appropriately.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2023 3:42:29 PM
Research Description
Brain aging from the epigenetic and physiological level to cognitive level. Students acquire skills in molecular or electrophysiological techniques to examination the influence of environmental and lifestyle factors on epigenetic regulation of gene transcription and synaptic plasticity mechanisms involved in memory.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/16/2023 1:50:41 PM
Research Description
O) Research Interest: Gene expression must be accurate in theory, however mRNA translation is surprisingly error-prone with 10% of nascent proteins having at least one error. These error products could stimulate protein aggregation with a progressive deterioration of protein homeostasis across aging. We approach disruptions in protein homeostasis from a protein production standpoint to understand how error products contribute to protein aggregation and the late onset of age-related neurodegenerative diseases. Our lab’s study of molecular mechanisms of translation error using cutting-edge biochemistry, molecular biology, and state-of-the-art genomics in yeast, mouse embryonic stem cell culture, and in vivo mouse models. We will provide crucial insight for the development of therapies for neurodegenerative disease.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/16/2023 1:54:43 PM
Research Description
1) Understanding how alterations in the microbiome can lead to promotion of gastrointestinal ailments using computational approaches.
Department:
Psychiatry
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
8/7/2023 7:50:48 AM
Research Description
Established in 2021, we are a research team with interests spanning neuroscience, genetics, and genomics. Our lab aims to integrate tools and techniques across these fields to better understand the genetic basis of psychiatric disorders, particularly within latinx communities. Our drive is based on helping in the contribution to the development of more targeted therapies for the treatment of psychiatric disorders.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/14/2023 2:19:50 PM
Research Description
I am a bacterial molecular pathogenesist, but I have closed my lab to focus on education in the last few years before I retire. I am not joining anymore graduate student supervisory committees, either.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/17/2022 12:42:12 PM
Research Description
Molecular pathways of embryonic development; vertebrate model systems of limb development; invertebral disk formation & disease using mouse models.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2023 12:31:36 PM
Research Description
Dr. Heldermon's primary focus is on developing new therapeutic strategies using gene therapy and stem cell therapy for patients with lysosomal storage disorders. He also studies therapy approaches for cancer focusing on breast and sarcoma.
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/14/2023 1:43:30 PM
Research Description
Dr. Ildefonso interest focuses on understanding the role of the ocular immunology in neurodegenerative diseases such as uveitis, diabetic retinopathy, and age-related macular degeneration. The translational emphasis of his research is retina neurodegeneration and to target it using adeno-associated viral vectors delivering anti-inflammatory or antioxidant genes.
Department:
Chemical Engineering
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2023 1:08:43 PM
Research Description
My research group is generating insights and solutions to problems with genome engineering, specifically CRISPR/Cas systems.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
7/13/2023 11:45:16 AM
Research Description
My research projects aim to understand mechanisms that drive initiation and progression of aortic aneurysms and dissections (AADs) and to identify critical cellular and molecular targets that hold promise for further translation to effective therapeutics. 1. Danger signals. Danger signals, particularly those triggered by damage associated molecular patterns (DAMPs), are double-edged swords that may facilitate or impair tissue-repairing processes. To this end, my laboratory focuses specifically on TLR-7 signaling incited by self-RNAs released from stressed or dying cells. Multiple mouse models and human tissue samples are employed to address the context-dependent effects of TLR-7 signaling in the development of AADs. 2. Dysregulated adaptive immune responses. Mounting evidence suggests that the biological outcome of immune injury to an organ depends on local immune cell differentiation. It has been postulated that type 2 immunity, a response primarily driven by Th2, NKT2, and ILC2 cells, may drive structural degeneration in target organs, such as the aorta. In contrast, type 1 immunity may direct cells to undergo hyperplastic responses. Since adaptive immunity is activated in human AADs, our lab is investigating the role of type 2 immunity in AAD development. 3. Impact of cytoskeleton deficiency on cell-signaling. Smooth muscle cells sense changes in the mechano-environment via their cytoskeleton system. They transduce mechano-stress into biochemical signals in order to maintain their mechano-homeostasis. Dysfunction of the cytoskeleton system has been implicated in the development of AADs. Currently, we are investigating risk factors, such as smoking and male gender, that render the aortic wall vulnerable to structural weakening and degeneration via impaired the cytoskeleton dynamics and signaling.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 10:37:42 AM
Research Description
Malformations of the maternal-fetal interface underlie many pregnancy pathologies and may also contribute to congenital malformations, all of which have acute and chronic sequelae for both mother and baby. My current and future research investigates the development and function and potential for treatment of this interface in 3 highly significant conditions; Fetal Growth Restriction, Congenital Heart defects and Placenta Accreta spectrum.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2023 1:30:22 PM
Research Description
Pathogenesis of noroviruses and virus-microbiota interactions, with a particular emphasis on understanding neonatal susceptibility to severe norovirus disease and maternal/microbial regulation of neonatal susceptibility.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2023 1:02:17 PM
Research Description
Dr. Kaye has a longstanding research interest in cancer genetics and translational clinical research. His lab studies the functional properties of a cAMP/CREB/CRTC pathway that is activated in cancer by loss of LKB1/AMPK signals in lung cancer. He also studies oncolytic virotherapy for small cell lung cancer with plans for a phase 1 clinical trial.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 10:58:59 AM
Research Description
Mammalian cell culture systems. Epigenetic regulation of transcription; chromatin structure and function; epigenetic silencing of tumor suppressor genes in cancer; single-molecule analysis of chromatin structure
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/16/2023 2:26:59 PM
Research Description
We study how cells communicate with each other to repair injured tissues including skeletal and cardiac muscle using sophisticated mouse genetics and state of the art cell biological tools.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/16/2023 1:47:21 PM
Research Description
Approximately 15% of cancers diagnosed were attributed to carcinogenic viral infections. Upon viral infections, the host innate immune system acts as the first line of defense to prevent viral invasion or replication, while viruses also strive for survival by repressing innate immune signaling. By further understanding how innate immunity is regulated by tumor viruses, our lab aims to dissect the interactions between innate immune responses and viral tumor development. Our long-term goal is to identify potential targets and strategies for viral cancer treatment. Utilizing molecular biology as well as bioinformatics tools, our lab seeks to extend our knowledge of how viral proteins regulate the cGAS-STING pathway and how to develop potential KSHV cancer therapy by targeting these viral proteins. Specifically, we are focusing on: 1) Exploring detailed mechanisms of cGAS-STING signaling regulation by KSHV viral proteins 2) Exploring the role of KSHV viral proteins on KSHV pathogenesis in vitro and in vivo 3) Screening for novel cGAS-STING pathway agonists, and testing their efficacy using PEL based xenograft mouse model
Department:
Surgery
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2023 12:40:59 PM
Research Description
My main research interest is to understand the acute and chronic immune dysfcuntion that occurs after severe trauma that is associated with increased susceptibility to devastating infections. I use an established mouse model of burn injury and have developed NIH-funded animal models of burn injury combined with radiation or inhalation injury to test potential countermeasures. I also have the unique ability to translate my findings with a large number of banked burn patient samples within a Burn Biorepository. My current major projects include: 1) focusing on DAMPs and TLR/mTOR-dependent activation of dysfunctional immune and metabolic responses after injury, investigating specific modulators of this interaction, 2) defining and implementing a rapid, point-of-care “immunosuppressive index” to allow better patient management, 3) investigating the role of NRF2 in inhalation injury and potential activation of that pathway to improve outcomes, and 4) investigating the role of extracellular vesicles in disease pathogenesis and as biomarkers of patient outcomes.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 11:37:39 AM
Research Description
Characterization of regulatory variants, genetic networks and molecular pathways underlying complex diseases such as adolescent idiopathic scoliosis. My research also includes studies exploring homeostasis of connective tissue and extracellular matrix.
Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/14/2021 3:39:29 PM
Research Description
Director of the Whitney Laboratory for Marine Bioscience. His research focus is aimed at elucidating the cellular and molecular basis for the evolution of cell-type complexity, regenerative biology, and cellular engineering.
Department:
Environmental Health
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2023 1:33:47 PM
Research Description
Pathogenic mechanisms of Shigella and Chlamydia
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2023 1:04:03 PM
Research Description
education research, clinical & translational science, team science
Department:
Biomedical Engineering
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 11:46:34 AM
Research Description
Vascular remodeling, wound healing and tissue engineering (vascular/bone/cartilage)
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/12/2023 1:02:34 PM
Research Description
My research employs proteomics, RNA-seq and capture-seq to study gene expression networks associated with gammaherpesvirus infections, how viruses exploit ion regulation, and to discover new viruses in human diseases of unknown etiology or emerging epidemiology at the human, animal or vector interface. Special emphasis is on elucidating complex molecular mechanisms of Epstein-Barr virus lytic activation, immune subversion, and cellular transformation relevant to virus-induced cancer as well as exploiting EBV to immortalize human B-cells to identify and clone antiviral antibodies.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/8/2022
Research Description
Focused on the use of statistical theory to elucidate the relationship between genotype and phenotype. Currently interested in integration of omic data.
Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/20/2019 11:50:20 AM
Research Description
Genomic Bases of Memory and Neuronal Evolution. Our laboratory works to characterize basic mechanisms underlying the design of nervous systems and the evolution of neuronal signaling mechanisms. The major questions are: (1) why are individual neurons so different? (2) How do learning and memory store in neuronal genomes and neural circuits? (3) How to restore memories? (4) How to make “better” neurons and brains and improve cognitive functions?
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
8/9/2023 8:07:37 AM
Research Description
Our lab uses molecular, genetic, and computational tools, animal models, patient-derived models to study the roles of tandem repeats and repeat expansions in disease and health as well as to identify novel therapeutic targets to treat disease. We aim to: 1) identify novel repeat expansions that contribute to Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and other neurodegenerative disorders 2) study how novel expansion mutations contribute to these diseases and the involvement of stress in triggering and exacerbating disease 3) study if and how tandem repeats regulate gene expression & function of the central nervous system
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 12:25:44 PM
Research Description
Exploring mechanisms of RNA metabolism that modulate vascular and hemtopoietic health and regeneration. Elucidating mechanisms of hematopoietic radioprotection through microenvironmental interactions.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 10:33:08 AM
Research Description
Uses human and mouse genetics to understand the causes and to develop therapies for genetic neurodegenerative diseases. A major focus in the lab is on diseases caused by repeat expansion mutations including ataxia, myotonic dystrophy and amyotrophic lateral sclerosis and dementia.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2023 1:12:00 PM
Research Description
Biology of Kaposi's sarcoma-associated herpesvirus (KSHV); role of latency-associated nuclear antigen (LANA) in transcriptional regulation, viral DNA replication, and episomal segregation in latently-infected cells; role of virus-encoded micro RNAs.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/16/2023 1:45:59 PM
Research Description
Genetic imprinting mechanisms and mouse models of imprinting disorders. Epigenetic reprogramming during germ cell development.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/20/2022 2:03:34 PM
Research Description
Molecular evolution of viruses, with special emphasis on HIV/SIV and SARS-CoV-2. Development and application of new bioinformatics and phylogenetic analysis tools to investigate the molecular epidemiology of microbial pathogens, with emphasis on RNA-virus
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2023 12:19:58 PM
Research Description
Prediction, immunopathogenesis, genetics and prevention and care of Type 1 diabetes.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/30/2023 8:33:36 AM
Research Description
My laboratory works on the fundamental biology of stem cells. Our goal is to design test and bring new cell based therapies to the clinic. How stem cells are involved in cancer and the creation of a supportive "cancer niche" are two primary areas of research
Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/14/2021 3:39:49 PM
Research Description
Research focus:the cellular and molecular mechanisms of development and regeneration in annelids and other closely related marine animals. Interests: patterning of embryonic stem cells, neurogenesis, regenerative biology and patterning of the germline.
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2023 1:11:59 PM
Research Description
Gene therapy of inherited retinal diseases
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/12/2023 12:57:29 PM
Research Description
For more than four decades, Dr. Srivastava’s research has been focused on the basic molecular biology of a non-pathogenic adeno-associated virus (AAV), and the development of the next generation of recombinant AAV vectors. The current emphasis is on gene therapy/genome editing of human blood diseases.

Megan L. Stanifer Ph.D.

Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2023 1:37:43 PM
Research Description
The Stanifer lab evaluates host/pathogen interactions at mucosal surfaces such as the human respiratory and intestinal tracts. We use primary organoid models to evaluate how and why individual cell types are infected and mount an antiviral immune response to clear the infection.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2023 12:17:43 PM
Research Description
Mouse models of tissue regeneration and neurological disease, mechanisms of mammalian development and aging, RNA biochemistry
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/26/2021
Research Description
Oncogenic virus pathogenesis, noncoding RNAs, virus-host interactions, host immunity to viruses, viral latency.
Department:
Physiological Sciences
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
7/13/2023 12:22:24 PM
Research Description
Genome wide CRISPR screens in Toxicology and Cancer Genetics of toxicants susceptibility Gene editing
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2023 12:23:01 PM
Research Description
Mutation and analysis of human disease susceptibility genes, and tumor genetics.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
4/26/2022
Research Description
Our current research falls within the general themes of host-pathogen interactions, and is divided into two major areas 1) Molecular studies of HIV and HCV pathogenesis and drug resistance and 2) Ecology of indigenous microbial communities associated with human infections.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/16/2021
Research Description
We study microsatellite repeat expansion diseases, including myotonic dystrophy. We use molecular, cellular, computational, and animal-based approaches to understand basic mechanisms that cause symptoms in this and related multi-systemic diseases, as well as identify treatments that will help patients. We also study RNA localization at a basic level, to understand why and how RNA molecules move to different places in the cell. We seek to combine high-throughput genomics approaches with single molecule imaging approaches to characterize and understand this new frontier in biology.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 12:08:48 PM
Research Description
We study aberrant cancer cell signaling with the goals of gaining molecular insights into cancer pathogenesis and identifying novel cancer diagnostic and therapeutic targets.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2023 12:44:33 PM
Research Description
The Xie Lab’s research interest is to decipher molecular mechanisms that modulate RNAs essential for gene expression in metazoans and associated Herpesviruses. Our current focus is on microRNAs, small non-coding RNA molecules that control the function of other genes. In the near future, we will integrate approaches from biochemistry, cell biology, virology and bioinformatics to study viral and cellular non-canonical microRNA biogenesis pathways, which surprisingly incorporate several fundamental cellular machineries involved in processing other classes of RNAs. Our efforts will provide a better basis for developing novel therapeutics that alter microRNA levels to combat a variety of diseases, including Herpesvirus-induced malignancies and other cancers.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/16/2020
Research Description
General Neuropathology. Neurodegenerative diseases.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/8/2022
Research Description
Apoptosis, regulation of innate immunity, innate immunity against tumor cells.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/13/2023 12:21:46 PM
Research Description
Gene Therapy, AAV vector design, AAV vector production, Directed Evolution, Machine Learning.

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