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- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/16/2023 2:11:59 PM
- Research Description
- Bacteria-Host Interactions, Microbe-Microbe interactions, Systemic infections, Oral infections, Intracellular Bacteria, Biofilms, bacterial genetics and physiology
- Department:
- Infectious Diseases and Immunology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 11:53:25 AM
- Research Description
- Cellular and molecular bases of host-parasite interactions; immunology of hemoparasitic diseases.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/12/2023 1:16:25 PM
- Research Description
- Dr. Atkinson’s research focuses on organ transplantation and chronic respiratory diseases. His organ transplant studies utilize numerous in-vitro and vivo models to dissect immune mechanisms that lead to donor organ injury, ischemia reperfusion injury, acute and chronic rejection. Chronic respiratory studies focus on aberrant complement system activation and autoreactivity.
- Department:
- Pediatrics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 12:12:08 PM
- Research Description
- Sumita Bhaduri-McIntosh is a physician-scientist whose research bridges the fields of Virology, Oncology and Immunology. Research in the Bhaduri laboratory is focused on discovering fundamental biological pathways and understanding cancer development and progression by studying the interaction between Epstein-Barr virus (EBV; a cancer-causing herpesvirus) and its host, the B cell, by investigating two main areas: 1) investigating how EBV subverts anti-pathogen and anti-cancer barriers such as immune responses and the DNA-damage response (DDR) to drive B cell proliferation and transformation, and 2) identifying host factors that determine susceptibility of EBV-infected B cells to lytic activation, a process important for herpesvirus pathology and persistence in humans, and for lymphomagenesis.
- Department:
- Molecular Genetics & Microbiology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/11/2023 3:50:01 PM
- Research Description
- Molecular pathogenesis of the herpesviruses; role of long non-coding RNAs and miRNAs on latency and reactivation; development of novel therapeutics to disrupt HSV latency and block recurrent disease.
- Department:
- Molecular Genetics & Microbiology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/13/2023 1:22:24 PM
- Research Description
- We study how enteric viral pathogens (rotavirus, norovirus, astrovirus…) infect and replicate in the human gastro-intestinal tract. We aim at defining how host/enteric pathogen interactions is coordinated at the molecular level in space and time and how these complex interactions can either lead to pathology development or resolution of viral infection. Our goal is to exploit these mechanisms to develop novel antiviral therapeutic approaches and pharmacological interventions to treat inflammatory bowel diseases. We use a multidisciplinary approach combining molecular and cellular biology, state-of-the-art live single molecule imaging, bio-engineering (to simulate the physiological microenvironment) and single cell transcriptomic approaches. Our integrative research approach allows us to address within a tissue how individual cell types communicate together to coordinate different antiviral strategies to ultimately lead to viral clearance while maintaining tissue homeostasis.
- Department:
- Pediatrics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2023 12:01:21 PM
- Research Description
- Optimizing gene therapy vectors (AAV) for the treatment of inherited retinal disease.
- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/13/2023 11:38:20 AM
- Research Description
- Streptococcal protein translocation; stress responses; membrane biogenesis; biofilm formation; bacterial adhesion; functional amyloid formation; host/pathogen interactions; immunomodulation by monoclonal antibodies; structure/function of streptococcal sur
- Department:
- Medicine
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 1:22:52 PM
- Research Description
- The goal of our work is to understand how misfolded alpha-1-antitrypsin causes cellular injury in liver and innate immune cells and to develop rational therapies to modulate this injury. To accomplish this goal we use cellular and animal models and transl
- Department:
- Institute for Therapeutic Innovation
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/14/2023 2:55:42 PM
- Research Description
- My research focuses on designing optimized therapeutic regimens for antiviral compounds active against viruses that pose a significant threat to global public health including influenza virus, dengue virus, Zika virus, chikungunya virus, hepatitis C, and SARS-CoV-2.
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 12:56:45 PM
- Research Description
- Regulation of immunity & autoimmunity; prediction, intervention, and treatment for type 1 diabetes. The lab is focused on immune system hetergeneity and development with age, as well as the mechanisms by which regulatory T cells maintain peripheral immune tolerance in the context of type 1 diabetes.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/14/2023 2:14:46 PM
- Research Description
- My lab studies the response of blood vessels within the lung to immunoregulatory cell recruitment, and how this may contribute to the development of high blood pressure in the lungs (pulmonary hypertension; PH), and heart failure, in patients with chronic lung diseases. Specific pathways of interest include: circadian biology influence on PH (models and patients with disease), free DNA sensing pathway, and exploring the contribution of dysautonomia to PH.
- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/13/2023 2:30:51 PM
- Research Description
- Environmental regulation of bacterial gene expression and virulence.
- Department:
- Pediatrics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2021 12:57:02 PM
- Research Description
- Cardiovascular gene therapy; adeno-associated viral vectors.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2021
- Research Description
- Characterize the immune suppressor mehanisms involved in the develeopment of HCC in the background of cirrhosis to identify novel targets that can lead to development of new immune activating strategies, predictive and prognostic biomarkers.
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 12:29:11 PM
- Research Description
- My laboratory is examining mechanisms for loss of human beta cells in type 1 diabetes and ways to regenerate functional beta cell mass. We are also examining the mechanisms underlying a smaller pancreas size in at risk first degree relatives and patients with type 1 diabetes. Studies are conducted using human biospecimens, isolated islets, mouse models (transgenic and AAV-injected) and beta cell lines with experiments focused on the role of neurotransmitters and neurohormones in beta cell regeneration and gene expression within endocrine and exocrine cells. Techniques include IHC, ISH, laser microdissection, optical clearing, microscopy (brightfield, fluorescence, confocal, lightsheet), in vitro cell proliferation/apoptosis, transfection, RNA and RNAseq analysis, Western blot, and other molecular biology techniques.
- Department:
- Oral Diagnostic Sciences, Oral Medicine Division
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 10:49:48 AM
- Research Description
- Pathogenesis of autoimmune Sjogren's disease Innate immunity of Sjogren’s disease. PKR sensing of mitochondrial dsRNA in childhood Sjogren’s disease Salivary gland regeneration Diagnostic/therapeutic strategies
- Department:
- Pediatrics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/12/2023 10:04:18 AM
- Research Description
- My current research as an Assistant Professor in the Department of Pediatrics focuses on understanding the contribution of neurological impairment in neuromuscular disorders by combining my expertise in clinical assessment and novel gene therapy approaches to restore muscular and the neurological impairments in neuromuscular disease.
- Department:
- Ophthalmology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 12:24:01 PM
- Research Description
- Dr. Dinculescu received her Ph.D. in Biochemistry from University of Florida in 2002. Her research is focused on understanding the molecular mechanisms in several retinal degeneration disorders, including Usher syndrome. The ultimate goal is to develop therapeutic strategies to prevent the loss of sight caused by these disorders. Usher syndrome type III (USH3A), an autosomal recessive disorder, is caused by mutations in Clarin-1 (CLRN1) protein, leading to combined vision and hearing loss. The main goal of this project is to understand the function of CLRN1 in the retina, identify its binding partners, and its cellular localization pattern. This information will be used to develop a rational treatment for the USH3A disorder. She is also interested in protein aggregation mechanisms leading to the formation of extracellular deposits associated with vision loss in age-related macular degeneration, a major cause of blindness in the elderly population.
- Department:
- Infectious Diseases and Immunology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/22/2023 12:50:02 PM
- Research Description
- Systems biology of vector borne disease transmission of pathogens such as Malaria, Dengue, Zika, and Yellow Fever; Vaccine Development; Drug Screening; Diagnostics
- Department:
- Animal Sciences
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/23/2020
- Research Description
- Strategies to enhance the immunity of domestic animals and the transfer of the resulting discoveries for the improvement of human health.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 12:59:46 PM
- Research Description
- Infectious Diseases, mathematical modeling, chemotherapy,
Lynn El Haddad, Ph.D.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 8/31/2022
- Research Description
- Bacteriophages as Modulators of Bacterial Colonization
- Department:
- Pediatrics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/12/2023 12:51:50 PM
- Research Description
- Effect of immunosuppression on anti-GAA antibody development in patients with Pompe disease, clinical trial studies as part of CARRA (Childhood Arthritis and Rheumatology Research Alliance)
- Department:
- Neurology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 12:53:58 PM
- Research Description
- Dr. Farrer's research aims to predict and prevent Parkinson’s disease through a combination of human genetic analyses, molecular genetic engineering and neuronal biology, mouse modeling, behavior, brain slice biochemistry and immunohistochemistry, electrophysiology and pharmacology. He directs the Parkinson’s Research Laboratory. Dr. Farrer also directs the Clinical Genomics Program for UF Health that seeks to improve health outcomes for patients by generating and interrogating genomic data, to accelerate diagnosis and target treatments more appropriately.
- Department:
- Neurosurgery
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/13/2023 12:18:20 PM
- Research Description
- Dr. Flores' research interests are focused on the development of cell-based immunotherapeutic strategies against CNS malignancies.
- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 11:44:26 AM
- Research Description
- Molecular mechanisms of periodontal diseases. Oral microbiome-host interactions Metatranscriptome of the oral microbiome in health and disease
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/16/2023 1:54:43 PM
- Research Description
- 1) Understanding how alterations in the microbiome can lead to promotion of gastrointestinal ailments using computational approaches.
- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 12:03:22 PM
- Research Description
- Research in my lab is focused in areas of host-pathogen interaction geared toward developing a better understanding of the host mechanisms and bacterial structures important in infection-elicited inflammation that relate to disease establishment and progression. We are particularly interested in understanding how bacteria and host interact in the context of the chronic oral inflammatory disease periodontal disease - using the model oral pathogen Porphyromonas gingivalis. We apply a variety of approaches including immunological, microbiological, molecular, and animal modeling in our research. Ongoing collaborative projects focus on microbial sphingolipids as mediators controlling inflammation as well as microbial CRISPR elements as key structures impacting bacterial virulence and host pathogen interaction.
- Department:
- Molecular Genetics & Microbiology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/14/2023 2:19:50 PM
- Research Description
- I am a bacterial molecular pathogenesist, but I have closed my lab to focus on education in the last few years before I retire. I am not joining anymore graduate student supervisory committees, either.
- Department:
- Pediatrics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 10:38:30 AM
- Research Description
- His Dr. Gupta's clinical interests include pediatric heart failure and transplantation, congenital heart disease, cardiomyopathy and mechanical circulatory support. Please visit the above link for latest grant support and academic contributions.
- Department:
- Pediatrics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 11:20:05 AM
- Research Description
- Prevention and Reversal of Type 1 diabetes
- Department:
- Medicine
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2023 2:46:26 PM
- Research Description
- Development of anti-infective countermeasures for bacterial infections of bio-warfare or bio-terrorism potential. Development of aerosol infection models.
- Department:
- Psychiatry
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/8/2019
- Research Description
- 1. Gene therapy using recombinant adeno-associated virus-based vectors for the treatment of brain and thyroid disorders 2. Parvovirus-host interactions
- Department:
- Pediatrics
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 11:48:26 AM
- Research Description
- The major focus of my research group is aimed at immune modulation and tolerance induction using cell and adeno-associated virus (AAV) viral gene therapies. We are developing novel gene immunotherapies that are capable of inducing antigen-specific regulatory T cells (Tregs) as a therapeutic intervention for autoimmune and genetic disease such as Multiple Sclerosis, optic neuritis, celiac disease, etc.
- Department:
- Ophthalmology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/14/2023 1:43:30 PM
- Research Description
- Dr. Ildefonso interest focuses on understanding the role of the ocular immunology in neurodegenerative diseases such as uveitis, diabetic retinopathy, and age-related macular degeneration. The translational emphasis of his research is retina neurodegeneration and to target it using adeno-associated viral vectors delivering anti-inflammatory or antioxidant genes.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/6/2022
- Research Description
- Innate defense mechanisms against resistant Gram-negative bacteria Influenza and emerging infectious diseases including SARS CoV2 and Zika
- Department:
- Pediatrics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/14/2023 3:08:15 PM
- Research Description
- Dr. Jacobsen’s research focuses on understanding the natural history type 1 diabetes, disease heterogeneity, and the use of immunotherapies to alter the progression of type 1 diabetes and biomarkers of response to therapy.
- Department:
- Chemical Engineering
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2023 1:08:43 PM
- Research Description
- My research group is generating insights and solutions to problems with genome engineering, specifically CRISPR/Cas systems.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2023 12:00:25 PM
- Research Description
- 1) Common human STING alleles; 2) Mucosal vaccines; 3) Lung immunity
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/24/2017
- Research Description
- Microbial pathogenesis, antibiotic resistance, microbial genetics, molecular epidemiology, microbial ecology.
- Department:
- Molecular Genetics & Microbiology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/13/2023 1:30:22 PM
- Research Description
- Pathogenesis of noroviruses and virus-microbiota interactions, with a particular emphasis on understanding neonatal susceptibility to severe norovirus disease and maternal/microbial regulation of neonatal susceptibility.
- Department:
- Biomedical Engineering
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/23/2022 1:04:14 PM
- Research Description
- The Biomaterial Immuno-Engineering Lab focuses on the engineering of biomaterial-cell interactions, and targeted controlled release of immune modulating factors in order to direct immune cell function.
- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 12:51:46 PM
- Research Description
- The current focus of our laboratory is to define the role of host response and inflammation in the context of influenza and influenza-associated secondary bacterial infections. We are actively investigating how influenza virus develops an exuberant host response implicated in immune-mediated lung pathology that exacerbates viral pneumonia and make influenza-infected lungs permissive to secondary bacterial infections. Because host response plays a double-edged role in executing viral control and driving collateral lung damage, our long-term goal is to de-couple protective vs. pathologic components of host response during influenza and secondary infections. We use a multifaceted approach focusing on multiple immune cells, such as CD8+ T cells and myeloid cells, to determine the crucial interplay between inflammatory cells and their communication with non-hematopoietic (alveolar epithelial) cells that result in acute lung damage. Further, we are evaluating multiple newly developed next generation vaccines against bacterial pneumonia.
- Department:
- Microbiology & Cell Science
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/11/2023 3:44:02 PM
- Research Description
- Our overall goal is to elucidate the mechanisms by which Leishmania parasites persist in infected hosts. Specifically, we investigate how the parasite's niche within macrophages is formed. In addition, we seek to identify the virulence factors that Leishmania elaborate
- Department:
- Urology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 11:22:53 AM
- Research Description
- Our current research is focused on cancer immunotherapy of primary and metastatic urologic cancers using preclinical animal models of prostate, bladder, and kidney cancers.
- Department:
- Periodontology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/20/2022
- Research Description
- Role of dominant microRNAs in periodontal disease (Current new Funded study). Major interests are to examine the role of major periodontal pathogens causal association with systemic diseases including Alzheimer’s disease, atherosclerosis, and rheumatoid arthritis.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/27/2017
- Research Description
- Dr. Lauzardo is a medical doctor who is an associate professor in the department of medicine. He serves as chief of the division of infectious diseases and global medicine. He is an expert on tuberculosis and refugee health issues. Dr. Lauzardo’s research is focused on the molecular epidemiology of tuberculosis and tuberculosis transmission.
- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/20/2023 12:14:23 PM
- Research Description
- Research in my lab focuses on deciphering the virulence mechanisms of the opportunistic nosocomial pathogen Enterococcus faecalis and the dental pathogen Streptococcus mutans. Ongoing projects include characterization of (i) global stress regulator Spx in S. mutans, (ii) regulatory nucleotides in E. faecalis, and (iii) studies to identify and determine the importance of mechanisms of metal homeostasis to the pathophysiology of both species.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 10:36:05 AM
- Research Description
- My group uses sophisticated in vitro and murine infection models to develop regimens for investigational and marketed antibiotics that maximize the killing of bacterial “superbugs” and prevent other bacteria from becoming “superbugs.” The interaction of the immune system with antibiotic(s) to kill microbes is also evaluated.
- Department:
- Molecular Genetics & Microbiology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/16/2023 1:47:21 PM
- Research Description
- Approximately 15% of cancers diagnosed were attributed to carcinogenic viral infections. Upon viral infections, the host innate immune system acts as the first line of defense to prevent viral invasion or replication, while viruses also strive for survival by repressing innate immune signaling. By further understanding how innate immunity is regulated by tumor viruses, our lab aims to dissect the interactions between innate immune responses and viral tumor development. Our long-term goal is to identify potential targets and strategies for viral cancer treatment. Utilizing molecular biology as well as bioinformatics tools, our lab seeks to extend our knowledge of how viral proteins regulate the cGAS-STING pathway and how to develop potential KSHV cancer therapy by targeting these viral proteins. Specifically, we are focusing on: 1) Exploring detailed mechanisms of cGAS-STING signaling regulation by KSHV viral proteins 2) Exploring the role of KSHV viral proteins on KSHV pathogenesis in vitro and in vivo 3) Screening for novel cGAS-STING pathway agonists, and testing their efficacy using PEL based xenograft mouse model
- Department:
- Surgery
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 12:40:59 PM
- Research Description
- My main research interest is to understand the acute and chronic immune dysfcuntion that occurs after severe trauma that is associated with increased susceptibility to devastating infections. I use an established mouse model of burn injury and have developed NIH-funded animal models of burn injury combined with radiation or inhalation injury to test potential countermeasures. I also have the unique ability to translate my findings with a large number of banked burn patient samples within a Burn Biorepository. My current major projects include: 1) focusing on DAMPs and TLR/mTOR-dependent activation of dysfunctional immune and metabolic responses after injury, investigating specific modulators of this interaction, 2) defining and implementing a rapid, point-of-care “immunosuppressive index” to allow better patient management, 3) investigating the role of NRF2 in inhalation injury and potential activation of that pathway to improve outcomes, and 4) investigating the role of extracellular vesicles in disease pathogenesis and as biomarkers of patient outcomes.
- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 11:51:07 AM
- Research Description
- My research focuses on elucidating the mechanisms of brain invasion by the AIDS-associated encapsulated fungus Cryptococcus neoformans and the interactions of this eukaryotic microbe with cells of the central nervous system including microglia, astrocytes, and neurons.
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 1:01:40 PM
- Research Description
- Genetics of resistance to autoimmune diabetes; oxidative burden of the beta cell.
- Department:
- Environmental Health
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/13/2023 1:33:47 PM
- Research Description
- Pathogenic mechanisms of Shigella and Chlamydia
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 1:04:03 PM
- Research Description
- education research, clinical & translational science, team science
- Department:
- Pediatrics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/12/2023 1:02:34 PM
- Research Description
- My research employs proteomics, RNA-seq and capture-seq to study gene expression networks associated with gammaherpesvirus infections, how viruses exploit ion regulation, and to discover new viruses in human diseases of unknown etiology or emerging epidemiology at the human, animal or vector interface. Special emphasis is on elucidating complex molecular mechanisms of Epstein-Barr virus lytic activation, immune subversion, and cellular transformation relevant to virus-induced cancer as well as exploiting EBV to immortalize human B-cells to identify and clone antiviral antibodies.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/14/2021
- Research Description
- Our lab studies mechanisms of lung immune response and repair in the context of infectious and non-infectious injury.
- Department:
- Infectious Diseases and Immunology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/23/2022
- Research Description
- Host and viral protein interactions relevant to therapeutic and vaccine development, Retrovirus vector for gene transfer based on foamy virus.
- Department:
- Vet Med- Research
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 1:50:07 PM
- Research Description
- Osteosarcoma; Melanoma vaccine; Stereotactic radiosurgery; Targeted radiotherapy; Tumor suppressor genes; single cell genomics; tumor microbiome, Nanostring.
- Department:
- Neurosurgery
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/11/2022
- Research Description
- Immunotherapy of adult and pediatric brain tumors. Mechanisms of resistance in brain tumors to immunologic rejection. Combinatorial therapeutics involving chemotherapy, radiation, and immunotherapy
- Department:
- Surgery
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/28/2018 12:53:08 PM
- Research Description
- The laboratory focuses on the innate and adaptive immune response to severe critical illness, including trauma, and surgical sepsis. Working with cell culture, animal models and clinical observation and interventional trials, the laboratory focuses on studying myelopoiesis, myeloid cell development, MDSCs and mature dendritic cell responses to severe trauma, severe sepsis, chronic critical illness and the PICS syndrome.
- Department:
- Vet Med- Research
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/28/2023 10:29:44 AM
- Research Description
- Malaria pathogenesis in pregnancy, focusing on coagulation, oxidative stress and cell deth mechanisms in human samples, mouse models and in vitro systems.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/22/2023 12:16:54 PM
- Research Description
- Dr. Moser’s lab studies how ubiquitin ligases regulate B cells to control antibody responses in viral infection and autoimmunity. Antibodies comprise a powerful arm of the immune system. Antibodies protect from infection, but can also cause autoimmune disease. Rotation projects would be to determine how the ubiquitin ligase "Itch" regulates GC B cells to 1) limit emergence of autoantibodies in lupus or 2) influence protective antibody responses in an influenza infection model.
- Department:
- Restorative Dental Sciences
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/17/2022
- Research Description
- My main research projects focus on investigating the relationship between oral alkali production from arginine and dental caries experience in children and adults.
- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2023 1:47:54 PM
- Research Description
- Research in Dr. Nguyen’s lab is focused on the immunopathogenesis of autoimmunity, especially Sjogren’s disease. To explore the development of autoimmunity, the lab focuses on three areas, 1) Examine the environmental triggers such as the SARS-CoV-2 infection, 2) Apply single-cell techniques to understand the interaction and regulation of individual immune cells in the affected organs, and 3) Use predictive modeling tools to identify and develop new therapeutic targets for precision medicine
M. Zehra Ordulu Sahin, MD.
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/13/2023 12:14:11 PM
- Research Description
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 11:11:14 AM
- Research Description
- Immune recognition, structural biology and drug discovery; cancer research; immunological regulation by T cells; structural interactions defined by X-ray crystallography and functional studies; drugs to prevent and treat COVID-19 .
- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 12:42:21 PM
- Research Description
- Interdisciplinary biomedical research; switch mechanisms in health versus disease; oncogenic viral infections and cancer; genome-wide studies; epigenetic and signaling regulation of cell identity
- Department:
- Biomedical Engineering
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/22/2023 1:23:24 PM
- Research Description
- Biomaterials engineering, type 1 diabetes, islet biology, immune engineering
- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/8/2022
- Research Description
- Molecular mechanisms of pathogenesis of gram-negative anaerobic bacterial species; bacterial/host cell interactions
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/13/2023 12:20:22 PM
- Research Description
- Pathogenesis of systemic lupus erythematosus in humans and animal models. Novel disease markers.
- Department:
- Molecular Genetics & Microbiology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 1:12:00 PM
- Research Description
- Biology of Kaposi's sarcoma-associated herpesvirus (KSHV); role of latency-associated nuclear antigen (LANA) in transcriptional regulation, viral DNA replication, and episomal segregation in latently-infected cells; role of virus-encoded micro RNAs.
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 8/1/2023 4:40:02 PM
- Research Description
- Responsible for instruction and mentorship of graduate students in conjunction with the Department of Pathology, Immunology and Laboratory Medicine academic programs including teaching a molecular evolution/phylodynamics, or genomics/bioinformatics course to students in the College of Medicine annually, training PhD students, contributing to the graduate curriculum. A significant amount of her time will also be dedicated to research and she is expected to develop a robust research program that will attract extra mural funding. Your research efforts will be in the field of HIV, Vibrio cholerae, SARS-CoV-2 and arboviruses evolution, molecular epidemiology, and pathogenesis, by applying next generation sequencing and single cell genomic technologies, as well as capable of developing bioinformatic analysis pipelines.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/24/2022 8:57:47 AM
- Research Description
- Dr. Schaller’s lab is focused on the immune cell interactions that occur during infection with SARS-CoV-2 and tuberculosis. He also has an interest in post-septic immunosuppression and sarcoidosis. Techniques used in Dr. Schaller's lab include flow cytometry, bioinformatic analysis and 3D culture of primary cells.
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 12:19:58 PM
- Research Description
- Prediction, immunopathogenesis, genetics and prevention and care of Type 1 diabetes.
- Department:
- Molecular Genetics & Microbiology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/30/2023 8:33:36 AM
- Research Description
- My laboratory works on the fundamental biology of stem cells. Our goal is to design test and bring new cell based therapies to the clinic. How stem cells are involved in cancer and the creation of a supportive "cancer niche" are two primary areas of research
- Department:
- Biomedical Engineering
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/28/2023 3:19:42 PM
- Research Description
- Lab research centers on engineering cell-based tissues for the treatment of Type 1 diabetes, specifically the development of novel biomaterials for: immunomodulation and promoting cellular engraftment
Megan L. Stanifer Ph.D.
- Department:
- Molecular Genetics & Microbiology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/13/2023 1:37:43 PM
- Research Description
- The Stanifer lab evaluates host/pathogen interactions at mucosal surfaces such as the human respiratory and intestinal tracts. We use primary organoid models to evaluate how and why individual cell types are infected and mount an antiviral immune response to clear the infection.
- Department:
- Surgery
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/22/2023 12:26:20 PM
- Research Description
- The lab of Dr. Thomas investigates the role of the microbiome in pancreatic carcinogenesis. They were one of the first labs to identify that the intestinal microbiota can accelerate pancreatic cancer progression and currently is focused on how bacterial metabolites interact with the innate immune system to modulate pancreatic carcinogenesis.
- Department:
- Molecular Genetics & Microbiology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/26/2021
- Research Description
- Oncogenic virus pathogenesis, noncoding RNAs, virus-host interactions, host immunity to viruses, viral latency.
- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 11:58:20 AM
- Research Description
- We study the molecular and cellular mechanisms of lifelong herpesvirus infections, focusing on the cancer-causing DNA virus called KSHV. We use KSHV mutants, proteomics, RNA and recombinant DNA technologies to identify and investigate the viral and host factors that are crucial in the regulation of KSHV infection.
- Department:
- Ophthalmology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2023 12:29:40 PM
- Research Description
- Dr. Tuli is board-certified in ophthalmology. Her interests include herpetic eye diseases, corneal transplants, ocular surface cancers, dry eye disease and infectious eye diseases.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/23/2022
- Research Description
- Dr. Amy Vittor studies factors that drive the emergence of vector-borne diseases. She conducted her doctorate on malaria and deforestation in the Peruvian Amazon, showing that a strong positive association exists between the abundance of malaria vectors and anthropogenic land use change. During her medical training, she treated patients with HIV and tuberculosis in Botswana, Kenya and Panama, and conducted malaria bed net implementation research in a United Nations Millennium Village in Ethiopia with the Earth Institute at Columbia University. Driven by a desire to better understand why arboviruses emerge where and when they do, she turned her attention to arboviral transmission. She studied dengue epidemiology in Kenya with the Centers for Disease Control and Prevention in Nairobi as a Fogarty International Clinical Fellow, and subsequently moved to Panama to examine the epidemiology of Venezuelan equine encephalitis and the emergent Madariaga encephalitis. At present, her research continues to look at the effect of land use change on vector-borne disease, but now also includes an examination of the role of host susceptibility and the population’s prior immune history. She also attends on the infectious diseases service at the University of Florida Shands hospital.
- Department:
- Physiological Sciences
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/13/2023 12:22:24 PM
- Research Description
- Genome wide CRISPR screens in Toxicology and Cancer Genetics of toxicants susceptibility Gene editing
- Department:
- Medicine
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 4/26/2022
- Research Description
- Our current research falls within the general themes of host-pathogen interactions, and is divided into two major areas 1) Molecular studies of HIV and HCV pathogenesis and drug resistance and 2) Ecology of indigenous microbial communities associated with human infections.
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 12:32:44 PM
- Research Description
- My laboratory focus is on the immunopathogenesis of Type 1 Diabetes (T1D). Aspects of this work include refining prediction of disease onset/progression through the use of genetics, autoantibody assessment. Current projects focus on functional interactions between endocrine/exocrine/immune cells in human pancreas using innovative 3D approaches (e.g., pancreas slice cultures, lightsheet microscopy, multiplexed immunofluorescence).
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 2:47:32 PM
- Research Description
- Diabetes research.
- Department:
- Pediatrics
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 12:26:50 PM
- Research Description
- The Wynn laboratory is focused on the investigation of neonatal-specific innate immune cellular function and inflammatory signaling during sepsis as well as development of novel therapeutic immunomodulatory strategies aimed at improving sepsis outcomes. Sepsis represents a significant clinical problem in the developmentally immature preterm neonate where attack rates may reach 60 percent with a 40 percent rate of death/major disability in developed countries. We employ both preclinical mechanistic investigations in association with observational human studies to improve our understanding of the neonatal-specific host response to sepsis. We use a wide variety of molecular and genetic techniques to interrogate the immune response viain vivo, ex vivo, and in vitro approaches. Applications of our work include improving the accuracy of sepsis diagnostic methods, identification of prognostic and clinical stratification markers, and discovery of potential opportunities for translational interventions aimed at improving infection-related outcomes.
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/16/2023 2:17:31 PM
- Research Description
- Mechanisms of irisin on converting white adipose tissue into brown adipose tissue for fighting obesity and type 2 diabetes; Roles of mesenchymal stem cells in regulating hematopoietic "niches" in normal and lupus patients; Transdifferentiation of human
- Department:
- Oral Biology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/21/2023 9:47:41 AM
- Research Description
- My research focuses on the metabolism of carbohydrates by oral bacteria, specifically how sugars affect bacterial behavior at the molecular level and contribute to oral health and diseases. Dental caries is the most prevalent infectious disease in humans, a condition caused by microbiome dysbiosis, or loss of balance in bacterial diversity, with overconsumption of sugar being the number one risk factor. The best defense against dental caries is a healthy microbiome. Our research has identified important features in sugar metabolism that separate pathogens from health-associated bacteria, and provided understanding in how these differences contribute to bacterial competitiveness and affect the virulence potential of dental plaque. One such example is our recent discovery that amino sugars may be able to modulate bacterial behavior in model systems to the detriment of a well-known caries pathogen, Streptococcus mutans. The ultimate goal of our program is to provide basic understanding needed to create or improve upon therapeutics toward more effective caries control. For a complete list of publications see: https://www.ncbi.nlm.nih.gov/myncbi/14ofj_mnGmAAd/bibliography/public/
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 12:50:59 PM
- Research Description
- Our research focuses on developing synthetic nanoplatforms to direct immune cells as ‘living therapeutics’, through genetically programming cellular functions or molecularly targeting stimulatory/inhibitory pathways. To this end, our lab integrates nanotechnology, immunology, synthetic biology, and clinically-relevant animal disease models to create novel nanotherapeutics for controlled modulation of the immune system.
- Department:
- Molecular Genetics & Microbiology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/8/2022
- Research Description
- Apoptosis, regulation of innate immunity, innate immunity against tumor cells.
- Department:
- Infectious Diseases and Immunology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/16/2023 1:43:50 PM
- Research Description
- The goal of my laboratory is to determine the transcriptional and metabolic regulation of immune responses, host-microbe interactions, and lymphocyte development in health and in disease.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2020
- Research Description
- Crohn’s Disease, Inflammatory Bowel Disease (IBD), Ulcerative Colitis 1) Molecular mechanism of fibrosis in Crohn's disease. The goal of this project is to determine the molecular mechanism whereby inflammation contributes to fibrosis in Crohn's disease using animal and cell culture models of the disease. 2) Therapy directed at preventing or treating fibrosis in IBD. The goal of this project is to identify pathways or novel therapies to prevent or treat fibrosis in Crohn’s disease. 3) Noninvasive method to detect fibrosis in Crohn's disease patients. The goal of this translational project is to develop methods to noninvasively detect fibrosis. This method will be used to monitor the natural history of Crohn's disease and determine the ability of new medications to alter the natural history of the disease. 4) Intestinal drug targeting. The goal of this work is to more effectively deliver drugs to regions of bowel using the oral route. This is aimed at decreasing systemic side effects of immunosuppressive medications. 5) Delivery of clinical care to IBD patients. Several prospective and retrospective projects examine pathogenesis, disease assessment, disease complications, and therapy outcomes in Crohn's disease and ulcerative colitis. A special area of interest is in care of college students with Crohn’s disease and ulcerative colitis.