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Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/19/2018 11:04:28 AM
Research Description
Our laboratory is interested in the molecular and cellular basis of aging. There are a number of mechanisms that contribute to the aging process at the molecular and cellular level. These mechanisms include, but are not limited to: (1) molecular damage
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
2/1/2019 7:44:54 AM
Research Description
Her research interests include several areas: (1) transcriptional and epigenetic control in anti-cancer immune therapies; (2) autoimmune diseases, including multiple sclerosis and inflammatory bowel disease; (3) cellular transformation in colon cancer and the impact of immune response and microbiota; (4) ubiquitin ligases in colon cancer; (5) ubiquitin ligases in immune response and their therapeutic use in autoimmunity. Her work has an important impact in development of immune therapies in cancer and treatments of autoimmune disorders.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/10/2016
Research Description
The goal of our work is to understand how misfolded alpha-1-antitrypsin causes cellular injury in liver and innate immune cells and to develop rational therapies to modulate this injury. To accomplish this goal we use cellular and animal models and transl
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 12:16:39 PM
Research Description
Regulation of immunity & autoimmunity; prediction, intervention, and treatment for type 1 diabetes. The lab is focused on the mechanisms by which regulatory T cells maintain peripheral immune tolerance in the context of type 1 diabetes.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/12/2017 9:11:54 AM
Research Description
Cell biology and biochemistry of actin-binding proteins involved in apoptosis, angiogenesis, neural plasticity and cancer biology.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/28/2018
Research Description
Characterize the immune suppressor mehanisms involved in the develeopment of HCC in the background of cirrhosis to identify novel targets that can lead to development of new immune activating strategies and/or prognostic and predictive immune biomarkers.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 12:07:02 PM
Research Description
My laboratory is examining mechanisms for loss of human beta cells in type 1 diabetes and ways to regenerate functional beta cell mass. Studies are conducted using human biospecimens, isolated islets, and beta cell lines with experiments focused on the role of neurotransmitters and neurohormones in beta cell regeneration. Techniques include IHC, ISH, laser microdissection, microscopy (brightfield, fluorescence, confocal), in vitro cell proliferation/apoptosis, transfection, RNA and RNAseq analysis, Western blot, and other molecular biology techniques.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/28/2018
Research Description
host-pathogen interactions; adaptive immune responses of chronic and tropical diseases.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 1:09:57 PM
Research Description
The current research projects are 1) studies of microRNAs in the regulation of toll-like receptor signaling pathways in innate immune response and their relationship to autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus and periodontal disease; 2) oral cancer pathogenesis and development of immunotherapy for these cancers.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2016 7:47:33 AM
Research Description
Translational research Cell-based therapy for type 1 diabetes Dr. Clare-Salzler is a JDRF, NIH-funded basic and clinical scientist investigating the autoimmune process that causes Type 1 Diabetes (T1D). The major focus of the laboratory is on the role o
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/11/2018 2:58:49 PM
Research Description
The Cogle Research Group is focused on clinical and laboratory research in stem cells and cancer. Projects include: (a) identification of novel agents & pathways for treatment of blood cancers, (b) using genomics to understand origins of blood cancers, (c) using genomics to understand drug response, discover new biomarkers and identify new drugs for treatment of patients with blood cancers.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/6/2017
Research Description
Developmental Biology & Evolution: Embryonic development of genitourinary organs; Genetic & genomic mechanisms of animal evolution; Genetic and environmental causes of birth defects
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018
Research Description
mechanisms of prostate and kidney cancer growth and metastasis, vesicle trafficking.
Department:
Vet Med- Research
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018
Research Description
Vector borne disease transmission of pathogens such as Malaria, Dengue, Zika, and Yellow Fever
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017
Research Description
Mechanisms and regulation of lysosomal degradation of cellular proteins and organelles in normal and diseased states. Therapeutic regulation of autophagy, pathway of organelle degradation, to treat cancer and other diseases.
Department:
Surgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/28/2018
Research Description
Dr. Efron has a professional interest in surgical critical care and trauma, both clinically as well as in the laboratory. He conducts basic science and translational research in sepsis and inflammation. He is currently one of the principal investigators for an NIH-funded P50 center grant for the UF Sepsis and Critical Illness Research Center to study the persistent inflammation, immunosuppression and catabolism syndrome (PICS) following sepsis in surgical intensive care unit patients. He also has his own NIH R01 funding regarding examining the hematopoietic response of the elderly to severe trauma. He was mentored by and now collaborates with Drs. Moldawer, Baker and Leeuwenburgh.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2018 9:03:36 AM
Research Description
Over the last five years, my lab has explored the function of carbonic anhydrase IX (CAIX) expression and activity in breast cancer. We hypothesize that CAIX is involved in regulating extracellular pH to the advantage of tumor cells.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2018
Research Description
Prevention and Reversal of Type 1 diabetes
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2018 9:13:17 AM
Research Description
My general interests are focused on the mechanisms and control of electrolyte and solute transport across epithelial membranes. In particular, I am interested in transport mechanisms for the oxalate anion across intestinal epithelial in the context of kidney stone disease
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2018 12:20:14 PM
Research Description
Gene expression, and gene delivery, gene therapy and functional genomics in the retina.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/28/2018 1:44:54 PM
Research Description
Dr. Heldermon's primary focus is on developing new therapeutic strategies using gene therapy and stem cell therapy for patients with inherited diseases such as lysosomal storage disorders and hemophilias. He is focused on studying the frequent cell transfer between mother and fetus during gestation that establish microchimerism and is determining ways to modulate the level of this chimerism to enable therapy of disease. Through the use of gene replacement, he hopes to correct the underlying deficiencies underpinning the disease manifestations. • Additionally he is studying the spread of breast malignancies through the use of xenografting. By studying the spread of tumors from breast cancer patients in mice, he hopes to determine if metastases is determined by tumor specific or host factors. This model will allow identification of what factors are important in tumor spread and localization. Additionally, the model will allow testing of therapeutic agents. The goal is to identify new targets for therapy to personalize oncologic therapeutics.
Department:
Orthodontics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 12:21:23 PM
Research Description
Regulation of bone remodeling and the generation of new tools for the treatment of bone disease. Recent studies are focused on extracellular vesicles (exosomesinvolved in regulating bone remodeling and on the generation of bone biomimetics.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018
Research Description
Research in the Huang lab is concentrated on elucidating molecular mechanisms associated with breast and ovarian cancer metastasis.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/6/2017 9:52:19 AM
Research Description
Chemoresistance in breast and prostate cancer, Nuclear Structure and Function, Epigenetic Regulation of Gene Expression tumor Suppression
Department:
Surgery
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 2:19:23 PM
Research Description
Aims to elucidate mechanisms of vascular remodeling that lead to vein graft failure, arterial restenosis, and aortic aneurysm development.

Lingtao Jin, PhD

Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
10/5/2018
Research Description
My research interest is focused on understanding the signaling basis of cancer metabolism, with focus on the function of metabolic enzymes and onco-metabolites in cancer and drug resistance. An ultimate goal is to apply the obtained insights to the development of molecular-targeted therapies to treat human cancers.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018
Research Description
Dr. Jobin is interested in bacteria/host interactions and ensuring innate/immunological responses during health and diseases. The intestine poses an interesting conundrum – it must peacefully cohabit with a sea of commensal bacteria (~100 trillion) and a high load of bacterial products, but swiftly respond to the presence of pathogenic micro-organisms that threaten its integrity. A major clinical consequence of deregulated bacteria/host interaction in the intestine is the development of inflammatory bowel diseases (IBD) and colorectal cancer. Using mice and zebrafish housed in germ-free and gnotobiotic conditions, microbiome techniques (next-generation sequencing, microbial gene mutations, microbial RNA-sequence, etc.), Dr. Jobin studies the differential contribution of bacteria in protecting or exacerbating development of colitis and colorectal cancer. Dr. Jobin has contributed to the understanding of the cellular and molecular mechanism regulating host response to bacterial colonization, and has published numerous papers on innate signaling events taking place in the intestine and how these impact intestinal homeostasis.

Richard J. Johnson, M.D.

Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Mechanisms of renal injury and progression, including in glomerulonephritis, diabetes, and hypertension.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
7/24/2017 10:13:40 AM
Research Description
Our current research interest is to understand the function of Nkx2.5, an evolutionarily conserved NK2 class of homeobox transcription factor in mature cardiomyocytes. Within the genomic analysis of cardiovascular diseases, mutations of NKX2.5 (capitals
Department:
Urology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 10:44:30 AM
Research Description
Our research is focused on tumor immunology, including immunotherapy and mechanisms of immune escape in urologic cancers (prostate, kidney, bladder) in both clinical and experimental settings.
Department:
Aging & Geriatrics Research
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 2:26:46 PM
Research Description
Physiology, biology & biochemistry of aging, with focus on MITOCHONDRIAL BIOLOGY, AUTOPHAGY, apoptosis and oxidative stress. Aging, oxidative stress, MITOCHONDRIA, AUTOPHAGY apoptosis, anti-aging interventions.
Department:
Chemical Engineering
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018
Research Description
Dr. Lele’s research is in the area of mechanobiology. We are interested in the mechanisms by which mechanical stresses on the nucleus impact gene expression in health and disease. The lab combines cutting edge microscope techniques, biophysical assays, genomics and molecular biology approaches to address hypotheses. Current collaborations are with Jonathan Licht (Director of Cancer Center), Jeffrey Nickerson (Anatomy and Cell Biology, U Mass medical school), Kyle Roux (Sanford Research), Richard Dickinson (UF Che) and Gregg Gundersen (Cell Biology, Columbia University). The lab has NIH-funded openings for PhD students.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 1:15:25 PM
Research Description
Cancer epigenetics focusing on enzymes (KATs and HDACs) that regulate protein acetylation using molecular, cellular and chemical biology approaches. We are also interested in discovering and optimizing small-molecule inhibitors of these enzymes for cancer therapy. Cancer metabolism is another area of research interest.
Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2018 1:42:19 PM
Research Description
Regulation of cell differentiation in the vertebrate retina and CNS and the molecular physiology of disease vector mosquito larvae. Molecular physiology of larval mosquito gut epithelium. Ageing of the cochlea.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 1:10:27 PM
Research Description
Epigenetic and metabolic regulation of tumor progression.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
12/10/2018
Research Description
Characterization of regulatory variants, genetic networks and molecular pathways underlying complex diseases. Her research also includes studies exploring homeostasis of connective tissue and extracellular matrix homeostasis as well as deciphering the role of non-coding variant genes in human disease.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2018 10:53:49 AM
Research Description
Molecular mechanisms of hematopoietic growth factor-induced cell signaling events regulating cell growth & apoptosis of normal and malignant hematopoietic cells; interleukin-3 regulation of tyrosine and serine/threonine protein kinases;

Peter McFetridge, Ph.D.

Department:
Biomedical Engineering
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 11:46:34 AM
Research Description
Vascular remodeling, wound healing and tissue engineering (vascular/bone/cartilage)
Department:
Periodontology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/3/2016
Research Description
We focus primarily on osteoimmunology, which is the study of interactions between immune cells, immune mediators, and immune signaling in skeletal biology. In particular, we study the differentiation of bone-resorbing osteoclast cells in response to bone
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/28/2018 12:49:46 PM
Research Description
Development of novel therapy for colorectal and breast cancers.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/28/2018 3:02:22 PM
Research Description
Studies on the cellular and molecular bases for inherited peripheral neuropathies and approaches to attenuate the accumulation of misfolded proteins within cells. Schwann cell biology, myelin formation, small molecule therapies and dietary approaches
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
5/23/2016 9:06:07 AM
Research Description
Genetic models for human vascular diseases; Studying pathogenetic mechanism of vascular malformation and pulmonary arterial hypertension: Preclinical studies targeting vascular malformatuon; development of the vascular system; Role of macrophages in development of arteriovenous malformations.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/14/2018
Research Description
Cytosine methylation is a heritable epigenetic modification affecting gene transcription and the integrity of the genome. In human malignancies, aberrant DNA methylation is the most commonly observed epimutation, often manifested by promoter hypermethylation of tumor suppressor genes and hypomethylation of intergenic non-coding regions. The DNA methyltransferases (DNMTs) DNMT1, DNMT3A, and DNMT3B are the enzymes primarily responsible for methylation of CpG dinucleotides in mammalian DNA. Mutations in the coding sequence of DNMT3A are frequently found in human hematologic malignancies indicating that decreased DNMT3A activity may promote tumorigenesis in multiple hematopoietic lineages. Using targeted inactivation of Dnmt3a in mice Opavsky lab showed that Dnmt3a plays a tumor suppressor role in prevention of chronic B-cell lymphocytic leukemia, peripheral T cell lymphoma and myeloproliferative disease. Furthermore, Dnmt3b is a tumor suppressor gene in prevention of MYC-induced T cell lymphomas. Promoter hypomethylation accompanied by increased gene expression was found to be a frequent event in both mouse and human hematologic malignancies.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
1/28/2019
Research Description
The Papp laboratory focuses on discovering critical genome-wide molecular mechanisms that control the identity of cells. Cell identity changes naturally during development and during regeneration. However, deregulation of cellular identity can cause diseases such as developmental disorders and cancer. By defining the critical transcription factors, epigenetic regulators and signaling pathway circuits that control the cell fate changes, we may be able to pinpoint novel targets for therapies. To this end, we apply state-of-the-art genomics approaches, single-cell imaging methods, functional genetics and biochemical approaches in various mouse and human cell types. Our approach is to (i) first perform an unbiased genome-wide study in order to (ii) identify key regulators of the complex process, (iii) which are then explored by functional studies leading to detailed mechanistic models.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/28/2018 1:47:12 PM
Research Description
Various stem cell (i.e. bone marrow, fetal, iPSCsand hepatic) biology and how they can be used as a tool in gene therapy or in their participation in liver regeneration. Also looking into how hepatic cells (hepatocytes, ductular cells, stellate cells) can be used in developing a bio-artificial liver device (BAL), bioengineering
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Molecular mechanisms of pathogenesis of gram-negative anaerobic bacterial species; bacterial/host cell interactions
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Neuronal cytoskeletal proteins especially microtubules, microfilaments and their associated proteins. Enzyme catalysis and regulation.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 1:46:35 PM
Research Description
Structure and function of Histone deacetylases, and their roles in gene regulation and cancer.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2018
Research Description
Genetic imprinting mechanisms and mouse models of imprinting disorders. Epigenetic reprogramming during germ cell development.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 12:34:09 PM
Research Description
Cellular and molecular mechanisms underlying normal and pathogenetic development of the cerebral cortex.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2018 9:49:27 AM
Research Description
Obesity and metabolic syndrome: inflammatory and prodiabetic effects of hyperuricemia and underlying signaling mechanisms responsible for these effects; role of ketohexokinase in the pathogenesis of obesity and the metabolic syndrome; molecular signaling; Intercellular communications in the adipose tissue (adipocytes, endothelial cells): signal transduction, exosomes, transcriptomics
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
5/23/2016 9:19:26 AM
Research Description
My laboratory works on the fundamental biology of stem cells. Our goal is to design test and bring new cell based therapies to the clinic. How stem cells are involved in cancer and the creation of a supportive "cancer niche" are two primary areas of res
Department:
Whitney Laboratories
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/9/2018 12:57:21 PM
Research Description
Research focus:the cellular and molecular mechanisms of development and regeneration in annelids and other closely related marine animals. Interests: patterning of embryonic stem cells, neurogenesis, regenerative biology and patterning of the germline.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017
Research Description
The focus of our lab is to investigate mechanisms of endothelial dysfunction and increased risk of atherosclerotic disease in unique patient populations. Our investigations range from bench research to translational studies involving patients with acute kidney injury, chronic kidney disease, or lupus.
Department:
Entomology & Nematology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
5/25/2016
Research Description
Genetic transformation of the obligate intracellular bacterium, Wolbachia, and it's use in paratransgenic introgression of genetic elements in insects.
Department:
Aging & Geriatrics Research
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 1:08:06 PM
Research Description
Molecular mechanisms underlying aging, detoxification, mitochondrial dysfunction, hearing loss, gender difference in aging
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018 12:49:45 PM
Research Description
Application of patient induced pluripotent stem (iPS) cells to clinical translational research;The role of mitochondrial ATP transporters in embryonic development, organ homeostasis and reproduction
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
4/11/2016
Research Description
My research program is focused understanding the mechanism of cancer metastasis and dormancy. The epithelial mesenchymal transition (EMT) is now suggested to play an important role in the initial invasion during cancer metastasis. However, direct in vivo evidence is currently lacking. Our lab is interested in understanding how cancer EMT contributes to cancer metastasis, and if so whether it also regulates cancer dormancy, a phenomenon in which micrometastatic disease is present in multiple organs but clinically undetectable.
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/28/2018 12:00:46 PM
Research Description
Dr. Tuli is board-certified in ophthalmology. Her interests include cataracts, corneal transplants, ocular surface cancers, dry eye disease and infectious eye diseases.
Department:
Radiation Oncology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017 7:52:38 AM
Research Description
Electrolyte and nutrient transport alteration in acute infectious and non infectious diarrheal conditions using electrophysiological techniques.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 4:37:29 PM
Research Description
The Vitriol lab uses live cell and super resolution microscopy to study the actin cytoskeleton in cell motility, neural development, and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS).
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2018 11:42:06 AM
Research Description
Molecular and epigenetic mechanisms infection and other inflammatory conditions underlying inflammatory polarization of antigen presenting cells (APC) including macrophages and dentritic cells in infectious disease (HIV-1) and autoimmune disease (type 1 diabetes).
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018
Research Description
Measurement of skeletal and cardiac muscle physiology, function, and metabolism using innovative NMR and MRI based techniques. Studies the effect of gene transfer/pharmacological correction from the basic cell level to humans with muscular dystrophies.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/1/2016
Research Description
We study microsatellite repeat expansion diseases, including myotonic dystrophy. We use molecular, cellular, computational, and animal-based approaches to understand basic mechanisms that cause symptoms in this and related multi-systemic diseases, as well as identify treatments that will help patients. We also study RNA localization at a basic level, to understand why and how RNA molecules move to different places in the cell. We seek to combine high-throughput genomics approaches with single molecule imaging approaches to characterize and understand this new frontier in biology.
Department:
Orthodontics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2018 3:19:06 PM
Research Description
Development and motor control of masticatory muscles. injury and repair of masticatory muscles; orofacial pain models.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/28/2018 8:49:14 AM
Research Description
We are studying cancer cell signaling with expertise in signal transduction, genetic and epigenetic regulation, and animal models. Our current laboratory research is centered on two families of transcriptional co-activators, MAML and CRTC, which are essential components of Notch receptor signaling and LKB1-CRTC/CREB signaling pathways, respectively. We are investigating the molecular regulation and the roles of deregulated cell signaling in cancer generation and progression, with the goal of gaining molecular insights into cancer pathogenesis and identifying novel cancer diagnostic and therapeutic targets.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/11/2018
Research Description
Mechanisms of irisin on converting white adipose tissue into brown adipose tissue for fighting obesity and type 2 diabetes; Roles of mesenchymal stem cells in regulating hematopoietic "niches" in normal and lupus patients; Transdifferentiation of human
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
5/23/2016 2:15:42 PM
Research Description
1. Molecular defects in immunoglobulin transcriptome repertoires in health and disease. 2. HIV-1 population structure, evolution, persistence and activation during disease progression. 3. HPV prevalence, population structure, persistence and fluctuation
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/28/2018 11:49:55 AM
Research Description
Mechanism of oncogenic transformation. Cooperation of oncogenes and suppressor genes in cancer development. Genetically engineered mice models for cancer. Targeted therapeutics in pancreatic and lung cancer models.
Department:
Pharmacodynamics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
1/15/2019
Research Description
Dr. Zhou’s research has been focused on investigation ofthe long-term effects of genotoxic stress/DNA damage induced by ionizing radiation (IR) and chemotherapy on hematopoietic stem cell (HSC) self-renewal and genomic stability; and the role of HSC injury in IR- and chemotherapy-induced long-term bone marrow suppression and leukemogenesis. His studies has led to a better understanding of the cellular and molecular mechanisms by which IR and chemotherapy cause normal tissue damage and the discovery of the first potent and broad-spectrum senolytic drug, ABT263-a specific Bcl-2/xl inhibitor, that can selectively kill senescent cells to rejuvenate both prematurely senescent tissue stem cells induced by IR and tissue stem cells in normally aged mice. This discovery may lead to new therapeutics for various age-related diseases and the side effects induced by chemotherapy and IR. More recently, he developed several proteolysis targeting chimeras (PROTACs) that can target Bcl-xl and other proteins of interest for degradation via the ubiquitination and proteasome system. He found that Bcl-xl PROTACs can selectively induce Bcl-xl degradation in senescent cells and various cancer cells but not in platelets, suggesting that Bcl-xl PROTACs have the potential to be developed as a better senolytic and anticancer agent than ABT263 by not causing thrombocytopenia. Using the PROTAC drug development platform, he is developing additional specific antitumor agents.

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