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Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2023 1:22:52 PM
Research Description
The goal of our work is to understand how misfolded alpha-1-antitrypsin causes cellular injury in liver and innate immune cells and to develop rational therapies to modulate this injury. To accomplish this goal we use cellular and animal models and transl
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2023 12:56:45 PM
Research Description
Regulation of immunity & autoimmunity; prediction, intervention, and treatment for type 1 diabetes. The lab is focused on immune system hetergeneity and development with age, as well as the mechanisms by which regulatory T cells maintain peripheral immune tolerance in the context of type 1 diabetes.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2023 1:10:48 PM
Research Description
Cell biology and biochemistry of actin-binding proteins involved in apoptosis, angiogenesis, neural plasticity and cancer biology.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2021
Research Description
Characterize the immune suppressor mehanisms involved in the develeopment of HCC in the background of cirrhosis to identify novel targets that can lead to development of new immune activating strategies, predictive and prognostic biomarkers.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2023 12:29:11 PM
Research Description
My laboratory is examining mechanisms for loss of human beta cells in type 1 diabetes and ways to regenerate functional beta cell mass. We are also examining the mechanisms underlying a smaller pancreas size in at risk first degree relatives and patients with type 1 diabetes. Studies are conducted using human biospecimens, isolated islets, mouse models (transgenic and AAV-injected) and beta cell lines with experiments focused on the role of neurotransmitters and neurohormones in beta cell regeneration and gene expression within endocrine and exocrine cells. Techniques include IHC, ISH, laser microdissection, optical clearing, microscopy (brightfield, fluorescence, confocal, lightsheet), in vitro cell proliferation/apoptosis, transfection, RNA and RNAseq analysis, Western blot, and other molecular biology techniques.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 11:54:46 AM
Research Description
Developmental Biology & Evolution: Embryonic development; Organ formation; Evo-Devo; Molecular basis of sex differences; Genetic and environmental causes of birth defects.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2023 2:05:31 PM
Research Description
mechanisms of prostate and kidney cancer growth and metastasis, vesicle trafficking and its role in urinary tract infection.
Department:
Infectious Diseases and Immunology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2023 12:50:02 PM
Research Description
Systems biology of vector borne disease transmission of pathogens such as Malaria, Dengue, Zika, and Yellow Fever; Vaccine Development; Drug Screening; Diagnostics
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2023 3:08:14 PM
Research Description
Mechanisms and regulation of lysosomal degradation of cellular proteins and organelles in normal and diseased states. Therapeutic regulation of autophagy, pathway of organelle degradation, to treat cancer and other diseases.
Department:
Surgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2022
Research Description
Dr. Efron has a professional interest in surgical critical care and trauma, both clinically as well as in the laboratory. He conducts basic science and translational research in sepsis and inflammation.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/14/2023 2:18:09 PM
Research Description
Circadian clocks are found in every cell and regulate predictive homeostasis through a daily program of gene expression. Our lab studies mechanisms through which 1) the clocks in skeletal muscle regulate muscle and systemic health; 2) how aging and diseases disrupt the clock contributing to diminished health and resilience; and 3) how exercise interacts with muscle and tissue clocks as a potential chrono-therapeutic.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2023 3:42:29 PM
Research Description
Brain aging from the epigenetic and physiological level to cognitive level. Students acquire skills in molecular or electrophysiological techniques to examination the influence of environmental and lifestyle factors on epigenetic regulation of gene transcription and synaptic plasticity mechanisms involved in memory.
Department:
Physics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2023 12:09:48 PM
Research Description
Protein phase separation, CRISPR gene editing for endogenous protein tagging, quantitative imaging of living cell, single-molecule dynamics of biomaterials
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 11:20:05 AM
Research Description
Prevention and Reversal of Type 1 diabetes
Department:
Aging & Geriatrics Research
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 11:50:28 AM
Research Description
Our currentresearch goal is to identify mechanisms that regulate the location and function of the mitochondria in two key neuronal conditions: injury (the regulation of axon regeneration) and maintenance (preserving normal synaptic function).
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2023 2:44:44 PM
Research Description
My general interests are focused on the mechanisms and control of electrolyte and solute transport across epithelial membranes. In particular, I am interested in transport mechanisms for the oxalate anion across intestinal epithelial in the context of kidney stone disease
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2023 12:31:36 PM
Research Description
Dr. Heldermon's primary focus is on developing new therapeutic strategies using gene therapy and stem cell therapy for patients with lysosomal storage disorders. He also studies therapy approaches for cancer focusing on breast and sarcoma.
Department:
Orthodontics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/8/2022
Research Description
Regulation of bone remodeling and the generation of new tools for the treatment of bone disease. Recent studies are focused on extracellular vesicles (exosomes) involved in regulating bone remodeling and on the generation of bone biomimetics.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2023 2:43:21 PM
Research Description
Research in the Huang lab is concentrated on elucidating molecular mechanisms associated with breast and ovarian cancer metastasis.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2023 12:58:27 PM
Research Description
Chemoresistance in breast and prostate cancer, Nuclear Structure and Function, Epigenetic Regulation of Gene Expression. tumor Suppression
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
7/13/2023 11:45:16 AM
Research Description
My research projects aim to understand mechanisms that drive initiation and progression of aortic aneurysms and dissections (AADs) and to identify critical cellular and molecular targets that hold promise for further translation to effective therapeutics. 1. Danger signals. Danger signals, particularly those triggered by damage associated molecular patterns (DAMPs), are double-edged swords that may facilitate or impair tissue-repairing processes. To this end, my laboratory focuses specifically on TLR-7 signaling incited by self-RNAs released from stressed or dying cells. Multiple mouse models and human tissue samples are employed to address the context-dependent effects of TLR-7 signaling in the development of AADs. 2. Dysregulated adaptive immune responses. Mounting evidence suggests that the biological outcome of immune injury to an organ depends on local immune cell differentiation. It has been postulated that type 2 immunity, a response primarily driven by Th2, NKT2, and ILC2 cells, may drive structural degeneration in target organs, such as the aorta. In contrast, type 1 immunity may direct cells to undergo hyperplastic responses. Since adaptive immunity is activated in human AADs, our lab is investigating the role of type 2 immunity in AAD development. 3. Impact of cytoskeleton deficiency on cell-signaling. Smooth muscle cells sense changes in the mechano-environment via their cytoskeleton system. They transduce mechano-stress into biochemical signals in order to maintain their mechano-homeostasis. Dysfunction of the cytoskeleton system has been implicated in the development of AADs. Currently, we are investigating risk factors, such as smoking and male gender, that render the aortic wall vulnerable to structural weakening and degeneration via impaired the cytoskeleton dynamics and signaling.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2023 12:30:07 PM
Research Description
Dr. Jobin works on microbiota and host response in the context of inflammation and carcinogenesis. His laboratory uses genomic, high throughput bacterial culture and gnotobiotic technology to dissect relationship between diet, inflammation and medication in human pathologies.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
1/23/2023 1:05:39 PM
Research Description
The long-term goal of Dr. Khodayari is to obtain knowledge and develop treatments for human diseases including, but not limited to, Liver disease and inflammatory diseases. Extracellular vesicles are critical in organ and cellular cross-talk. Dr. Khodayari’s interest is on the rule of extracellular vesicles and organ cross-talk in inflammatory diseases.
Department:
Urology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 11:22:53 AM
Research Description
Our current research is focused on cancer immunotherapy of primary and metastatic urologic cancers using preclinical animal models of prostate, bladder, and kidney cancers.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 11:35:07 AM
Research Description
Physiology, biology & biochemistry of aging, with focus on mitochondrial biology, autophagy, apoptosis, oxidative stress, anti-aging interventions and translation to clinical trials based on findings from pre-clinical models.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/20/2023 12:17:17 PM
Research Description
Cancer epigenetics focusing on enzymes (KATs and HDACs) that regulate protein acetylation using molecular, cellular and chemical biology approaches. We are also interested in discovering and optimizing small-molecule inhibitors of these enzymes for treating cancer. Cancer metabolism is another area of research interest.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/14/2023 2:28:08 PM
Research Description
Jonathan D. Licht, MD, is the Director of the University of Florida Health Cancer Center, Dr. Licht's laboratory studies aberrant epigenetics and gene regulation as a cause of hematological and other malignancies
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 11:39:48 AM
Research Description
Our behavior and physiology are distinctively different during the day vs. at night. The most obvious manifestation is the sleep/wake cycle which dictates the rest/activity and fasting/feeding cycles and all associated processes, collectively known as circadian (~24 h) rhythms. These rhythms are regulated by the endogenous circadian clocks; in fact, virtually every cell in our body has a clock. In the ideal world, these endogenous rhythms are aligned with the 24 h light/dark cycle. However, our modern life style imposes timing constrains that clash with circadian physiology, often causing health problems, including sleep and neuropsychiatric disorders, metabolic syndrome, cardiovascular diseases, and cancer. Chronotherapy and chronotherapeutics are an emerging concept in personalized medicine that considers circadian rhythms in medication and treatment. The major focus of the lab is to study the molecular, cellular and physiological mechanisms of the circadian clock in mammals. We use cells and mice as model systems and employ highly integrated approaches to study how the circadian clock keeps time. We ask i) how does the clock work, i.e. how circadian oscillations are generated in a cell and in the master clock in the brain, and ii) what does the clock do, i.e. how the molecular clock is integrated in cell and organ physiology. We use cultured mammalian cells and mice as models and study these circadian systems at both single gene/protein and genome-wide levels, and with not only spatial (within and between organs) but also temporal (day vs. night) resolution. We use highly integrated molecular, genetic and genomic approaches in our research. As an advisor and mentor, I am acutely aware of the need for future biologists to obtain balanced training and conduct independent research, and I believe our research setting provides such an opportunity for training future generation scientists.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 11:37:39 AM
Research Description
Characterization of regulatory variants, genetic networks and molecular pathways underlying complex diseases such as adolescent idiopathic scoliosis. My research also includes studies exploring homeostasis of connective tissue and extracellular matrix.
Department:
Biomedical Engineering
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 11:46:34 AM
Research Description
Vascular remodeling, wound healing and tissue engineering (vascular/bone/cartilage)
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/12/2023 1:09:22 PM
Research Description
The overarching goal of the Moehle Laboratory is to understand the cellular, molecular, and circuitry changes that underlie both the motor and non-motor symptoms of movement disorders, and to leverage these discoveries into novel therapeutic strategies for these disorders.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2023 12:16:54 PM
Research Description
Dr. Moser’s lab studies how ubiquitin ligases regulate B cells to control antibody responses in viral infection and autoimmunity. Antibodies comprise a powerful arm of the immune system. Antibodies protect from infection, but can also cause autoimmune disease. Rotation projects would be to determine how the ubiquitin ligase "Itch" regulates GC B cells to 1) limit emergence of autoantibodies in lupus or 2) influence protective antibody responses in an influenza infection model.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2023 12:47:11 PM
Research Description
Development of novel therapy for colorectal and breast cancers.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2023 12:39:22 PM
Research Description
Cytosine methylation is a heritable epigenetic modification affecting gene transcription and the integrity of the genome. In human malignancies, aberrant DNA methylation is the most commonly observed epimutation, often manifested by promoter hypermethylation of tumor suppressor genes and hypomethylation of intergenic non-coding regions. The DNA methyltransferases (DNMTs) DNMT1, DNMT3A, and DNMT3B are the enzymes primarily responsible for methylation of CpG dinucleotides in mammalian DNA. Mutations in the coding sequence of DNMT3A are frequently found in human hematologic malignancies indicating that decreased DNMT3A activity may promote tumorigenesis in multiple hematopoietic lineages. Using targeted inactivation of Dnmt3a in mice Opavsky lab showed that Dnmt3a plays a tumor suppressor role in prevention of chronic B-cell lymphocytic leukemia, peripheral T cell lymphoma and myeloproliferative disease. Furthermore, Dnmt3b is a tumor suppressor gene in prevention of MYC-induced T cell lymphomas. Promoter hypomethylation accompanied by increased gene expression was found to be a frequent event in both mouse and human hematologic malignancies.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2023 12:42:21 PM
Research Description
Interdisciplinary biomedical research; switch mechanisms in health versus disease; oncogenic viral infections and cancer; genome-wide studies; epigenetic and signaling regulation of cell identity
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/8/2022
Research Description
Molecular mechanisms of pathogenesis of gram-negative anaerobic bacterial species; bacterial/host cell interactions
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/16/2023 1:45:59 PM
Research Description
Genetic imprinting mechanisms and mouse models of imprinting disorders. Epigenetic reprogramming during germ cell development.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2023 12:48:36 PM
Research Description
Our research examines how cilia signaling contributes to brain development and cancer.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/30/2023 8:33:36 AM
Research Description
My laboratory works on the fundamental biology of stem cells. Our goal is to design test and bring new cell based therapies to the clinic. How stem cells are involved in cancer and the creation of a supportive "cancer niche" are two primary areas of research
Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/14/2021 3:39:49 PM
Research Description
Research focus:the cellular and molecular mechanisms of development and regeneration in annelids and other closely related marine animals. Interests: patterning of embryonic stem cells, neurogenesis, regenerative biology and patterning of the germline.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2023 12:26:55 PM
Research Description
The focus of our lab is to investigate mechanisms of endothelial dysfunction and increased risk of atherosclerotic disease in unique patient populations. Our investigations range from bench research to translational studies involving patients with acute kidney injury, chronic kidney disease, or lupus.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/22/2023 1:20:33 PM
Research Description
Molecular and cellular mechanisms underlying sex difference in hearing, cochlear aging, and hearing loss using genetic mouse models.

Megan L. Stanifer Ph.D.

Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2023 1:37:43 PM
Research Description
The Stanifer lab evaluates host/pathogen interactions at mucosal surfaces such as the human respiratory and intestinal tracts. We use primary organoid models to evaluate how and why individual cell types are infected and mount an antiviral immune response to clear the infection.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/16/2020
Research Description
Research in the Tran lab focuses on understanding the molecular mechanism of how cancer develops, progresses, and resists treatments through an integrated approach from clinical observations to systems and computational biology, and to animal models and quantitative molecular validation, with the ultimate goal of returning to human patients to develop novel, safe and effective anti-cancer therapeutics.
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2023 12:29:40 PM
Research Description
Dr. Tuli is board-certified in ophthalmology. Her interests include herpetic eye diseases, corneal transplants, ocular surface cancers, dry eye disease and infectious eye diseases.
Department:
Radiation Oncology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2023 12:40:43 PM
Research Description
1. Electrolyte and nutrient transport alteration in acute infectious and non infectious diarrheal conditions using electrophysiological techniques. 2. Pre-Clinical Tumor Models 3. Gastrointestinal motility and transit models 4. Cystic fibrosis
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2023 12:45:21 PM
Research Description
Measurement of skeletal and cardiac muscle physiology, function, and metabolism using innovative NMR and MRI based techniques. Studies the effect of gene transfer/pharmacological correction from the basic cell level to humans with muscular dystrophies.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/16/2021
Research Description
We study microsatellite repeat expansion diseases, including myotonic dystrophy. We use molecular, cellular, computational, and animal-based approaches to understand basic mechanisms that cause symptoms in this and related multi-systemic diseases, as well as identify treatments that will help patients. We also study RNA localization at a basic level, to understand why and how RNA molecules move to different places in the cell. We seek to combine high-throughput genomics approaches with single molecule imaging approaches to characterize and understand this new frontier in biology.
Department:
Orthodontics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/10/2021 2:12:32 PM
Research Description
Development and motor control of masticatory muscles, injury and repair of masticatory muscles; orofacial pain models; randomized clinical trials.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 12:08:48 PM
Research Description
We study aberrant cancer cell signaling with the goals of gaining molecular insights into cancer pathogenesis and identifying novel cancer diagnostic and therapeutic targets.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/16/2023 2:17:31 PM
Research Description
Mechanisms of irisin on converting white adipose tissue into brown adipose tissue for fighting obesity and type 2 diabetes; Roles of mesenchymal stem cells in regulating hematopoietic "niches" in normal and lupus patients; Transdifferentiation of human
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/13/2023 12:20:55 PM
Research Description
Mechanism of oncogenic transformation. Cooperation of oncogenes and suppressor genes in cancer development. Genetically engineered mice models for cancer. Targeted therapeutics in pancreatic and lung cancer models.

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