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- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 11:21:11 AM
- Research Description
- Our lab is interested in how myosin molecular motors generate force on actin filaments and how defects in this fundamental cytoskeletal mechanism cause human disease. We study these processes in neurons and auditory mechanosensory hair cells.
- Department:
- Neuroscience
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2021 12:23:32 PM
- Research Description
- Molecular mechanisms of age related cognitive decline and Alzheimer’s disease Neural circuits of decision making
- Department:
- Neuroscience
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/23/2020
- Research Description
- Develop technology and application of magnetic resource imaging and spectroscopy.
- Department:
- Physiological Sciences
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/8/2019
- Research Description
- A variety of neuromuscular diseases result in impaired cough (dystussia) and/or impaired swallow function (dysphagia). Cough and swallows are controlled by complex brainstem networks which, until recently, have been studied in isolation. However, in neuro
- Department:
- Anesthesiology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/14/2023 2:25:11 PM
- Research Description
- Understanding the molecular-physiological-through-behavioral neurobiology of motor, sensory and cognitive plasticity following pharmacotherapy and neurorehabilitation using preclinical (rodent) models of neurotrauma (spinal cord, traumatic brain injuries, stroke) and neurodegenerative diseases.
- Department:
- Institute for Therapeutic Innovation
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/14/2023 2:55:42 PM
- Research Description
- My research focuses on designing optimized therapeutic regimens for antiviral compounds active against viruses that pose a significant threat to global public health including influenza virus, dengue virus, Zika virus, chikungunya virus, hepatitis C, and SARS-CoV-2.
- Department:
- Psychiatry
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2021 12:56:31 PM
- Research Description
- Drug addiction is a chronic disorder that is characterized by compulsive drug taking and relapse after periods of abstinence. The research in our laboratory focuses on the development of non-addictive treatments for nicotine, alcohol, and opioid addiction
- Department:
- Pathology, Immunology & Laboratory Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 12:56:45 PM
- Research Description
- Regulation of immunity & autoimmunity; prediction, intervention, and treatment for type 1 diabetes. The lab is focused on immune system hetergeneity and development with age, as well as the mechanisms by which regulatory T cells maintain peripheral immune tolerance in the context of type 1 diabetes.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/14/2023 2:14:46 PM
- Research Description
- My lab studies the response of blood vessels within the lung to immunoregulatory cell recruitment, and how this may contribute to the development of high blood pressure in the lungs (pulmonary hypertension; PH), and heart failure, in patients with chronic lung diseases. Specific pathways of interest include: circadian biology influence on PH (models and patients with disease), free DNA sensing pathway, and exploring the contribution of dysautonomia to PH.
- Department:
- Neuroscience
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 12:34:08 PM
- Research Description
- Research involves studies on neuroinflammatory mechanisms of blood-brain barrier disruption in ischemic stroke
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/30/2023 8:31:54 AM
- Research Description
- Understanding the mechanistic basis for how endocrine dysregulation (age-related (menopause)/life-style (obesity/diabetes) and sex differences in these events impact CNS function and plasticity, and mediate increased risk of Alzheimer's disease.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/16/2023 1:52:50 PM
- Research Description
- Metabolism-Diabetes (T2DM); Obesity; Fatty Liver Disease (NAFDL). The main goals of our lab are to understand the metabolic and molecular pathways of T2DM, obesity and NAFLD.
- Department:
- Anatomy & Cell Biology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 2:05:31 PM
- Research Description
- mechanisms of prostate and kidney cancer growth and metastasis, vesicle trafficking and its role in urinary tract infection.
- Department:
- Anesthesiology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/23/2022
- Research Description
- Investigation of the clinically relevant anti-oxidant and anti-inflammatory drugs using in vivo preclinical models and human biospecimens of ischemic and hemorrhagic strokes, traumatic brain injury, Alzheimer, and other neurological disorders
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 12:59:46 PM
- Research Description
- Infectious Diseases, mathematical modeling, chemotherapy,
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/13/2023 1:39:27 PM
- Research Description
- Our laboratory studies the interplay between epigenetics and chromatin organization in acute myeloid leukemia (AML) and in pre-leukemic conditions. We use biochemistry, cell-based assays, -omics approaches, and genetic in vivo models to understand the molecular mechanisms that drive pre-leukemic clonal evolution and lead to malignant transformation. Our goal is to find and evaluate therapies that will help cancer patients.
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 12:22:00 PM
- Research Description
- The Hammers Lab researches physiological and pathophysiological mechanisms of skeletal and cardiac muscle, particularly those associated with genetic diseases known as muscular dystrophies. The primary motivation of these efforts is to identify potential therapeutic targets that can be exploited to develop treatments for muscle and heart diseases using small molecules and/or adeno-associated virus (AAV)-based gene therapies.
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/22/2023 1:08:04 PM
- Research Description
- Brain tumor immunotherapy. Chemokines and chemokine receptors in glioma. Focus on glioblastoma and pharmacological targeting using pre-clinical animal models
- Department:
- Neurosurgery
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2023 2:04:35 PM
- Research Description
- 1. Study the inflammatory healing response in aneurysms and develop novel tissue-engineered treatments and devices for aneurysms, 2. Study the inflammatory pathways that lead to the development of cerebral aneurysms, 3. Study mechanisms of injury after subarachnoid hemorrhage including vasospasm and delayed cerebral ischemia
- Department:
- Biomedical Engineering
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/23/2022 1:04:14 PM
- Research Description
- The Biomaterial Immuno-Engineering Lab focuses on the engineering of biomaterial-cell interactions, and targeted controlled release of immune modulating factors in order to direct immune cell function.
- Department:
- Neuroscience
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 12:19:09 PM
- Research Description
- Dysregulation of dopamine transmission is involved in Parkinson’s Disease, drug addiction, compulsivity and altered peripheral immunity. Our research is focused on studying how changes in the peripheral immunity affect dopamine transmission in the central nervous system.
- Department:
- Microbiology & Cell Science
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/11/2023 3:44:02 PM
- Research Description
- Our overall goal is to elucidate the mechanisms by which Leishmania parasites persist in infected hosts. Specifically, we investigate how the parasite's niche within macrophages is formed. In addition, we seek to identify the virulence factors that Leishmania elaborate
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/16/2023 2:26:59 PM
- Research Description
- We study how cells communicate with each other to repair injured tissues including skeletal and cardiac muscle using sophisticated mouse genetics and state of the art cell biological tools.
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 12:31:02 PM
- Research Description
- Our research focuses on the roles of the CUB Domain-Containing Protein 1 (CDCP1) protein which facilitates the invasion, survival, and metastasis of breast tumors, and the TRAIL/Death Receptor 5 (DR5) pathway that selectively kills cancer cells. We are investigating therapeutic strategies for blocking the oncogenic functions of CDCP1, and have identified a novel class of agents that activate DR5 to kill cancer cells by promoting disulfide bond-dependent DR5 clustering and downstream activation of the pro-apoptotic Caspase enzymes.
- Department:
- Neurology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2023 12:46:42 PM
- Research Description
- Dr. Li’s research is mainly focused on the pathophysiology and experimental therapeutics of dystonia, restless legs syndrome, ALS/FTD. He is also broadly interested in animal models of movement disorders and molecular and cellular mechanisms of synaptic plasticity during development and adult learning and memory.
- Department:
- Ophthalmology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/22/2023 12:46:15 PM
- Research Description
- Our lab is focused on the understanding of age-related changes in lipid and protein metabolism in neurons in the eye. We are using a broad range of modern cell and molecular biology methods, including gene editing, mass spectrometry, gene therapy, high-resolution microscopy and structural imaging, and transcriptional studies, to study and develop effective approaches to treat human blindness.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/13/2023 10:36:05 AM
- Research Description
- My group uses sophisticated in vitro and murine infection models to develop regimens for investigational and marketed antibiotics that maximize the killing of bacterial “superbugs” and prevent other bacteria from becoming “superbugs.” The interaction of the immune system with antibiotic(s) to kill microbes is also evaluated.
- Department:
- Medicinal Chemistry
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/30/2020
- Research Description
- Dr. Luesch’s multidisciplinary research program at the interface of chemistry and biology combines classical natural products chemistry with high-throughput screening and chemical genomics. It involves most aspects of drug discovery ranging from the collection of promising marine organisms, bioassay development, NMR spectroscopic structure determination, total synthesis, mechanism-of-action studies, and pharmacology, up to the preclinical and clinical development of candidate molecules. His lab is producing a small but increasing pipeline of bioactive compounds that are at various developmental stages. He also uses functional genomics approaches to identify and characterize genes associated with disease processes, especially cancer and neurological disorders.
- Department:
- Anesthesiology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/21/2022 4:14:14 PM
- Research Description
- Mechanisms of intergenerational neurocognitive abnormalities induced by parental exposure to general anesthesia
Christopher McCurdy, Ph.D.
- Department:
- Medicinal Chemistry
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/12/2023 1:05:43 PM
- Research Description
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 7/12/2023 1:09:22 PM
- Research Description
- The overarching goal of the Moehle Laboratory is to understand the cellular, molecular, and circuitry changes that underlie both the motor and non-motor symptoms of movement disorders, and to leverage these discoveries into novel therapeutic strategies for these disorders.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2023 2:23:46 PM
- Research Description
- Dr. Moore’s main areas of research are the mechanistic mathematical modeling of diseases, evaluation of mechanistic model predictions, and mathematical optimization of combination drug regimens.
- Department:
- Whitney Laboratories
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/20/2019 11:50:20 AM
- Research Description
- Genomic Bases of Memory and Neuronal Evolution. Our laboratory works to characterize basic mechanisms underlying the design of nervous systems and the evolution of neuronal signaling mechanisms. The major questions are: (1) why are individual neurons so different? (2) How do learning and memory store in neuronal genomes and neural circuits? (3) How to restore memories? (4) How to make “better” neurons and brains and improve cognitive functions?
- Department:
- Otolaryngology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/13/2023 10:54:46 AM
- Research Description
- Dr. Mulligan’s serves as the Vice Chair of Research & Director of Resident Research Education in the Department of Otolaryngology. Her laboratory focuses on examining inflammatory diseases of the upper and lower airways with a significant emphasis on chronic rhinosinusitis (CRS). In collaboration with other laboratories, we also conduct research on mechanism of olfactory in CRS and identifying novel therapeutics to treat lung transplant rejection. Research areas includes basic science, translation studies and clinical trials conducted through partnerships with clinicians in the UF Division of Rhinology & Sinus Surgery and other sites across the US.
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/11/2023 3:52:24 PM
- Research Description
- Smell disorders such as anosmia are associated with numerous diseases and disorders (including upper respiratory viral infections such as COVID-19, traumatic brain injury, and neurodegenerative diseases). They also significantly reduce quality of life. Our team is focused on understanding how smell function varies in healthy people and in different patient populations, and in developing novel testing strategies to objectively assess that function.
- Department:
- Orthodontics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/10/2021 2:44:59 PM
- Research Description
- Neurophysiology of pain; inflammation and neuropathic pain; chronic pain mechanisms; translational research for chronic pain.
- Department:
- Neurology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/12/2023 1:14:07 PM
- Research Description
- Dr. Okun’s laboratory has focused on identifying the physiological brain signature patterns for tics and other movement disorders, and also has been focused on the development of neurotechnology for a closed loop solution to tic disorders. Dr. Okun’s research efforts have also been focused on the motor and non-motor aspects of deep brain stimulation as applied to basal ganglia disorders.
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 1:09:05 PM
- Research Description
- Physiology, pharmacology, and biophysics of neurotransmitter receptors especially the function of nicotinic acetylcholine receptors in the brain. We are additionally interested in addiction and the development of drug cessation therapies for smokers and people addicted to the use of betel quid.
- Department:
- Physiological Sciences
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/30/2020
- Research Description
- Hepatotoxicity, immunotoxicity, metabolism, kinetics and risk assessment, nanotoxicology
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/30/2022 1:59:49 PM
- Research Description
- Topoisomerases; cancer and microbial chemotherapy; mitochondrial DNA; chromatin structure. Malaria, plastid/organellar DNA and anti-malarial drugs.
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/22/2023 12:21:16 PM
- Research Description
- The emphasis of my research program is on understanding the underlying molecular and cellular mechanisms resulting in autoimmune Type 1 diabetes (T1D) in humans, with a focus on the insulin-producing beta cells. My lab uses primary human tissues and pluripotent stem cell derived functional tissues (pancreatic, thymic and neuronal cells) in conjugation with genome engineering approaches (CRISPR/Cas9 and TALEN) to advance cell replacement therapy and establish novel model system that allow us to interrogate previously inaccessible biological questions in a strictly human context. We are a group of diverse individuals that seek to better ourselves and our research with the goal of challenging existing scientific dogmas and positively impact society and patients' life alike. If you are interested, please do reach out to holger.russ@ufl.edu
- Department:
- Surgery
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/15/2023 8:17:09 AM
- Research Description
- Dr. Sharma directs two research laboratories that investigate the molecular mechanisms of aortic aneurysm pathogenesis and pathophysiology of post-lung transplant injury. Current projects are focused on how dying/apoptotic cells are eaten up by endothelial cells and macrophages, and if the dysregulation of this process (efferocytosis) causes vascular and pulmonary inflammation and injury. His laboratories also focus on mechanistic studies to decipher the crosstalk between parenchymal cells such as endothelial and smooth muscle cells, with immune cells like macrophages and neutrophils, involving excess iron-mediated cell death (ferroptosis), in the pathophysiology of aortic aneurysms and lung ischemia-reperfusion injury. His research interests also include therapeutic application of mesenchymal stem cell-derived extracellular vesicles in attenuating vascular and pulmonary disease processes. His laboratory is nationally renowned in scientific research of aortic aneurysm and lung transplant injury. Research methodologies/techniques used in his laboratories involve investigation of human samples and murine experimental models entailing surgical models, flow cytometry, RNA/protein analysis, spatial transcriptomics and scRNA sequencing etc.
- Department:
- Radiation Oncology
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/13/2023 11:57:39 AM
- Research Description
- Our research laboratory seeks to improve cancer therapies through molecular targeting strategies and physiologic interventions such as exercise. A primary focus is the tumor microenvironment which not only influences treatment resistance of cancer to conventional anticancer therapies but also plays a critical role in neoplastic cell initiation, malignant progression, and metastatic spread to secondary sites.
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 7/13/2023 10:45:21 AM
- Research Description
- neuromuscular diseases
- Department:
- Surgery
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/21/2023 9:22:28 AM
- Research Description
- Treating patients with aortic aneurysms with novel endovascular and pharmacologic therapies.
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/14/2023 10:26:54 AM
- Research Description
- What motivates us? Motivation is the drive to perform actions to achieve goals, and is crucial for survival. In neurobiology, motivation is regulated by combination of movement (action) and reward/pleasure (reinforcer), which ensures that an animal achieves its goals consistently. Lack of or too much motivation can be harmful, and has been implicated in the etiology of various disorders such as depression, schizophrenia, ADHD, Parkinson’s and drug addiction. Dopamine is at the center of regulating movement, reward-based learning and motivation, and dopamine dysfunction has been implicated in all of the above disorders. The goals of our lab are to identify and map neuronal circuits that regulate dopamine signaling, motivation, movement and reward, by using state of the art tools such as viral tracing, opto/chemogenetics, fiber photometry, and operant behavioral conditioning. Deciphering the mechanisms that regulate dopamine neuronal circuits and motivation will allow us to develop novel therapeutic strategies to treat disorders such as addiction, depression and schizophrenia.
- Department:
- Radiation Oncology
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2023 12:40:43 PM
- Research Description
- 1. Electrolyte and nutrient transport alteration in acute infectious and non infectious diarrheal conditions using electrophysiological techniques. 2. Pre-Clinical Tumor Models 3. Gastrointestinal motility and transit models 4. Cystic fibrosis
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/23/2022 2:05:17 PM
- Research Description
- Dr. Wesson’s research focuses on the neural processing of sensory information in the context of motivated behaviors. His research utilizes in vivo electrophysiological methods, including chronic neural recordings from defined brain regions, optical methods to image the activity of genetic- and projection-specific circuits (fiber photometry, 2-photon microscopy), as well as optogenetic, chemogenetic, and pharmacological manipulations – all in animals engaged in sophisticated behavioral tasks we custom design.
- Department:
- Orthodontics
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - No
- Last Updated
- 6/10/2021 2:12:32 PM
- Research Description
- Development and motor control of masticatory muscles, injury and repair of masticatory muscles; orofacial pain models; randomized clinical trials.
- Department:
- Pharmacology & Therapeutics
- Concentrations:
- Accepting Students
- Yes
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/22/2023 12:42:25 PM
- Research Description
- We are interested in understanding the fundamental biology of the interactions between genetic factors and environmental factors in the process of animal aging.
- Department:
- Medicine
- Concentrations:
- Accepting Students
- No
- Accepting Students if
Funding Obtained - Yes
- Last Updated
- 6/15/2020
- Research Description
- Crohn’s Disease, Inflammatory Bowel Disease (IBD), Ulcerative Colitis 1) Molecular mechanism of fibrosis in Crohn's disease. The goal of this project is to determine the molecular mechanism whereby inflammation contributes to fibrosis in Crohn's disease using animal and cell culture models of the disease. 2) Therapy directed at preventing or treating fibrosis in IBD. The goal of this project is to identify pathways or novel therapies to prevent or treat fibrosis in Crohn’s disease. 3) Noninvasive method to detect fibrosis in Crohn's disease patients. The goal of this translational project is to develop methods to noninvasively detect fibrosis. This method will be used to monitor the natural history of Crohn's disease and determine the ability of new medications to alter the natural history of the disease. 4) Intestinal drug targeting. The goal of this work is to more effectively deliver drugs to regions of bowel using the oral route. This is aimed at decreasing systemic side effects of immunosuppressive medications. 5) Delivery of clinical care to IBD patients. Several prospective and retrospective projects examine pathogenesis, disease assessment, disease complications, and therapy outcomes in Crohn's disease and ulcerative colitis. A special area of interest is in care of college students with Crohn’s disease and ulcerative colitis.